Recent List of Publications in Menopause

A woman in a white shirt is wearing a gray scarf

The musculoskeletal syndrome of menopause.

Wright VJ, Schwartzman JD, Itinoche R, Wittstein J.Climacteric. 2024 Oct;27(5):466-472. doi: 10.1080/13697137.2024.2380363. Epub 2024 Jul 30.PMID: 39077777 Free article. Review.

As the ovarian production of estrogen diminishes in midlife and ultimately stops, it is estimated that more than 47 million women worldwide enter the menopause transition annually. More than 70% will experience musculoskeletal symptoms and 25% will be disabled by them thro …

Vitamin D and Menopause.

Sharma M, Kalra S.J Pak Med Assoc. 2024 Apr;74(4):815-817. doi: 10.47391/JPMA.24-27.PMID: 38751288 Review.

Menopause is the transition period in female life cycle. Resultant hormonal changes lead to adverse health effects. ...Vitamin D deficiency is a globally prevalent problem. Vitamin D deficiency in menopausal women may aggravate the adverse health risks associated wi …

Menopause transition and cardiovascular disease risk.

Uddenberg ER, Safwan N, Saadedine M, Hurtado MD, Faubion SS, Shufelt CL.Maturitas. 2024 Jul;185:107974. doi: 10.1016/j.maturitas.2024.107974. Epub 2024 Mar 22.PMID: 38555760 Review.

There is increasing evidence that the menopause transition is a risk factor for CVD, independent of age-related changes, especially considering that the earlier the onset of menopause, the greater is the CVD risk. ...In this review, we summarize the current literatu …

Obesity and menopause.

Palacios S, Chedraui P, Sánchez-Borrego R, Coronado P, Nappi RE.Gynecol Endocrinol. 2024 Dec;40(1):2312885. doi: 10.1080/09513590.2024.2312885. Epub 2024 Feb 11.PMID: 38343134 Free article. Review.

Obesity is not a choice or a result of lack of willpower, but a multifactorial, chronic, progressive, and relapsing disease. During menopause, hormonal and body composition changes lead to greater visceral adiposity, that aggravates women's health at a cardiometabolic, mec …

A systematic review and critical appraisal of menopause guidelines.

Hemachandra C, Taylor S, Islam RM, Fooladi E, Davis SR.BMJ Sex Reprod Health. 2024 Apr 11;50(2):122-138. doi: 10.1136/bmjsrh-2023-202099.PMID: 38336466

Acknowledged potential long-term menopause consequences were urogenital atrophy, and increased risks of cardiovascular disease and osteoporosis. VMS and menopause-associated mood disturbance were the only consistent indications for systemic menopausal hormone …

Menopause and endometriosis.

Cassani C, Tedeschi S, Cucinella L, Morteo V, Camnasio CA, Tiranini L, Martini E, Nappi RE.Maturitas. 2024 Dec;190:108129. doi: 10.1016/j.maturitas.2024.108129. Epub 2024 Sep 26.PMID: 39357143 Free article. Review.

However, conclusive data regarding the appropriateness of menopausal hormone therapy in women with endometriosis or a history of the disease are lacking. Current recommendations lean towards prioritizing combined menopausal hormone therapy formulations or tibolone o …

Menopause depression: Under recognised and poorly treated.

Kulkarni J, Gurvich C, Mu E, Molloy G, Lovell S, Mansberg G, Horton S, Morton E, Uppal T, Cashell C, de Castella A, Reisel D, Dear L, Weatherburn-Reeves N, Harris K, Pietrobon K, Teagle K, Kim BY, Newson L, Szoeke C.Aust N Z J Psychiatry. 2024 Aug;58(8):636-640. doi: 10.1177/00048674241253944. Epub 2024 May 18.PMID: 38761367 Free PMC article.

Many women leave the workforce earlier than expected due to menopause-related depression and anxiety, with subsequent loss of salary and superannuation. ...We are a large and diverse group of national and international clinicians, lived experience and social community advo …

Menopause and mental health.

Horst K, Cirino N, Adams KE.Curr Opin Obstet Gynecol. 2025 Apr 1;37(2):102-110. doi: 10.1097/GCO.0000000000001014. Epub 2025 Feb 25.PMID: 39970050 Review.

PURPOSE OF REVIEW: This review discusses mental health changes commonly experienced by individuals during the menopause transition (MT). The pathophysiology of the MT, the chronology and type of mental health symptoms arising from this pathophysiology, and evidence-based o …

Pain during menopause.

Strand NH, D'Souza RS, Gomez DA, Whitney MA, Attanti S, Anderson MA, Moeschler SM, Chadwick AL, Maloney JA.Maturitas. 2025 Jan;191:108135. doi: 10.1016/j.maturitas.2024.108135. Epub 2024 Oct 31.PMID: 39500125 Review.

While often associated with hot flashes, mood swings, and hormonal changes, pain is a frequently overlooked and under-addressed aspect of the menopausal experience. This review article explores the multifaceted nature of pain during menopause, and sheds light on its …

Menopause and metabolic dysfunction-associated steatotic liver disease.

Polyzos SA, Goulis DG.Maturitas. 2024 Aug;186:108024. doi: 10.1016/j.maturitas.2024.108024. Epub 2024 May 14.PMID: 38760254 Review.

The association between menopause and metabolic dysfunction-associated steatotic liver disease renders menopausal hormone therapy an appealing way to reverse hepatic disease in parallel with the benefits of menopausal hormone therapy in other tissues. ...This …

Menopause mysteries: the exosome-inflammation connection.

Sultania A, Brahadeeswaran S, Kolasseri AE, Jayanthi S, Tamizhselvi R.J Ovarian Res. 2025 Jan 23;18(1):12. doi: 10.1186/s13048-025-01591-9.PMID: 39849635 Free PMC article. Review.

The movement and proteins of these exosomes are crucial in the regulation of cellular communication and the aging of cells, a process termed inflammaging. Menopause, a natural progression in the aging of females, is often accompanied by numerous negative symptoms and healt …

Menopause and Alzheimer's disease susceptibility: Exploring the potential mechanisms.

Breeze B, Connell E, Wileman T, Muller M, Vauzour D, Pontifex MG.Brain Res. 2024 Dec 1;1844:149170. doi: 10.1016/j.brainres.2024.149170. Epub 2024 Aug 18.PMID: 39163895 Review.

Despite this, our understanding of this female AD vulnerability remains limited. Menopause has been identified as a potential contributing factor to AD in women, with earlier menopause onset associated with greater AD risk. ...This review examines the potential role …

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Menopause and MHT in 2024: addressing the key controversies - an International Menopause Society White Paper.

Panay N, Ang SB, Cheshire R, Goldstein SR, Maki P, Nappi RE; International Menopause Society Board.Climacteric. 2024 Oct;27(5):441-457. doi: 10.1080/13697137.2024.2394950. Epub 2024 Sep 13.PMID: 39268862 Free article. Review.

The aim of this White Paper is to provide a well-balanced educational narrative of the menopause and menopause hormone therapy (MHT) from IMS experts, leading into World Menopause Day 2024. This is achieved by exploring the anthropology and history of meno …

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Management of obesity in menopause.

Palacios S, Chedraui P, Sanchez-Borrego R, Coronado P, Simoncini T, Schauding K, Hillard T, Nappi RE.Climacteric. 2024 Aug;27(4):357-363. doi: 10.1080/13697137.2024.2374760. Epub 2024 Jul 17.PMID: 39016333 Review.

The role of physicians and gynecologists is pivotal in the multidisciplinary approach to obesity management during menopause. Gynecologists are often the primary health-care providers for menopausal women and are in a unique position to offer guidance on weight mana …

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Associations Between Menopause and Depression.

Hawkins SS.J Obstet Gynecol Neonatal Nurs. 2025 Jan;54(1):20-31. doi: 10.1016/j.jogn.2024.12.004.PMID: 39681322 Review.

Menopause is a process of hormonal changes that typically starts in a woman's mid- to late 40s and is associated with an increased risk of depression. ...I conclude with information from professional organizations, but there are noted gaps in mental health resources for …

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A Contemporary View of Menopausal Hormone Therapy.

Levy B, Simon JA.Obstet Gynecol. 2024 Jul 1;144(1):12-23. doi: 10.1097/AOG.0000000000005553. Epub 2024 Mar 14.PMID: 38484309 Review.

Enthusiasm for the use of hormones to ameliorate symptoms of perimenopause and menopause has waxed and waned over the years. Both treatment for symptoms and training of women's health care practitioners in the management of menopause have sharply declined since publ …

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Is Early Menopause a Different Entity From Premature Ovarian Insufficiency?

Anagnostis P, Lambrinoudaki I, Goulis DG.Clin Endocrinol (Oxf). 2025 Jan;102(1):67-74. doi: 10.1111/cen.15136. Epub 2024 Sep 16.PMID: 39279431 Free PMC article. Review.

Early menopause (EM, defined as age at menopause < 45 years) is also associated with these adverse health consequences, in most cases to the same degree as in POI. Therefore, a unifying term for EM and POI, such as 'premature menopause', may be proposed, u

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Impact of menopause-associated frailty on traumatic brain injury.

Sinder SB, Sharma SV, Shirvaikar IS, Pradhyumnan H, Patel SH, Cabeda Diaz I, Perez GG, Bramlett HM, Raval AP.Neurochem Int. 2024 Jun;176:105741. doi: 10.1016/j.neuint.2024.105741. Epub 2024 Apr 14.PMID: 38621511 Review.

Menopausal transition is characterized by a decrease in estradiol-17beta (E2), and the impact of menopause resonates not only in the reproductive system but also through the central nervous system, musculoskeletal, and gastrointestinal domains. ...Understanding the …

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Menopause part I: Vasomotor symptoms (I).

Wang PH, Yang ST, Chang WH, Lee WL.Taiwan J Obstet Gynecol. 2025 Mar;64(2):230-238. doi: 10.1016/j.tjog.2025.01.001.PMID: 40049806 Free article. Review.

Menopause, an aged process due to loss of permanent ovarian function (mainly decreased production of estrogen) without another pathological or physiological cause becomes one of the most health issues in the world. Vasomotor symptoms (VMS) is a hallmark of menopause …

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Complementary and Alternative Medicine for Menopause.

Smith-Francis MJ.Nurs Clin North Am. 2024 Dec;59(4):551-562. doi: 10.1016/j.cnur.2024.08.001. Epub 2024 Sep 20.PMID: 39477563 Review.

Complementary and alternative medicine (CAM) has gained popularity as a naturalistic approach to managing menopausal symptoms. This evidence-based article reviews recent studies on the use of CAM for menopause and aims to provide insights into the effectiveness, saf …

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Diverse experiences of menopause.

Cortés YI.Menopause. 2025 Mar 1;32(3):278-280. doi: 10.1097/GME.0000000000002510. Epub 2025 Feb 21.PMID: 39998973 Review.

Although the biologic underpinnings of menopause remain consistent across populations, the experience of this phase can vary. This Practice Pearl summarizes key sociocultural, behavioral, environmental, and healthcare-system factors that contribute to the menopause …

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Sleep disturbance associated with the menopause.

Maki PM, Panay N, Simon JA.Menopause. 2024 Aug 1;31(8):724-733. doi: 10.1097/GME.0000000000002386. Epub 2024 Jun 25.PMID: 38916279 Review.

IMPORTANCE AND OBJECTIVES: Sleep disturbance is one of the most common and debilitating symptoms experienced by women during the menopause transition. However, there are currently no therapies specifically approved for sleep disturbance associated with the menopause …

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Mental Well-being in Menopause.

Green R, Metcalf CA, Santoro N.Obstet Gynecol Clin North Am. 2025 Mar;52(1):51-66. doi: 10.1016/j.ogc.2024.10.002. Epub 2024 Nov 16.PMID: 39880566 Review.

The hormonal changes that accompany the transition to menopause are disruptive to most women, and for some, mental health maybe adversely affected. Depressive symptoms and major depression are the best-studied conditions in association with menopause, but anxiety, e …

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Estrogen deficiency in the menopause and the role of hormone therapy: integrating the findings of basic science research with clinical trials.

Yang JL, Hodara E, Sriprasert I, Shoupe D, Stanczyk FZ.Menopause. 2024 Oct 1;31(10):926-939. doi: 10.1097/GME.0000000000002407. Epub 2024 Jul 30.PMID: 39081162 Review.

Menopause, defined by the cessation of menstrual cycles after 12 months of amenorrhea not due to other causes, is associated with significant hormonal changes, primarily a decrease in estrogen, androgen, and progesterone levels. ...Here, we first outline the variation in e …

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Sleep disturbance and menopause.

Carmona NE, Solomon NL, Adams KE.Curr Opin Obstet Gynecol. 2025 Apr 1;37(2):75-82. doi: 10.1097/GCO.0000000000001012. Epub 2025 Jan 17.PMID: 39820156 Review.

PURPOSE OF REVIEW: Sleep problems are among the most prevalent and bothersome symptoms of menopause. This review characterizes menopausal sleep disturbances, describes biopsychosocial predictors, and summarizes the evidence supporting pharmacological and nonpharmaco …

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Menopause experiences in sexual minority women and non-binary people.

Sobel T, Derakshani D, Vencill JA.Maturitas. 2024 Jul;185:108007. doi: 10.1016/j.maturitas.2024.108007. Epub 2024 Apr 24.PMID: 38677174 Review.

This review provides an overview of their experiences with menopause, including menstrual cessation, menopause symptoms, experiences with healthcare systems, and sexual health. ...So, too, do sexual minority women and non-binary people report negative experiences wi …

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Menopause and Sexual Health: Hormones, Aging or Both?

Nappi RE, Cucinella L.Clin Obstet Gynecol. 2025 Mar 1;68(1):44-50. doi: 10.1097/GRF.0000000000000910. Epub 2024 Dec 2.PMID: 39618033 Review.

At midlife, women may face challenges to sexuality, often requiring intervention. Menopause-related and age-related hormonal changes intermingle with common medical conditions and contribute to biological substrates less favorable to a healthy sexual response. ...A compreh …

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Sexual Dysfunction After Menopause: Guidelines for Assessment and Management.

Christmas MM, Reed S.Obstet Gynecol Clin North Am. 2024 Jun;51(2):341-364. doi: 10.1016/j.ogc.2024.02.007. Epub 2024 Apr 4.PMID: 38777488 Review.

Female sexual dysfunction commonly occurs during the menopause transition and post-menopause due to hormonal, physiologic, and psychosocial factors. ...

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Effectiveness and safety of fezolinetant in alleviating vasomotor symptoms linked to Menopause.: A systematic review and Meta-Analysis.

Elnaga AAA, Alsaied MA, Elettreby AM, Ramadan A.Eur J Obstet Gynecol Reprod Biol. 2024 Jun;297:142-152. doi: 10.1016/j.ejogrb.2024.04.017. Epub 2024 Apr 15.PMID: 38640780

BACKGROUND & OBJECTIVE: Vasomotor symptoms (VMS) are the most common symptoms during menopause including hot flushes and night sweats. They are highly disruptive to the quality of life. ...These reductions were positively reflected on Menopause specific quality …

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Systematic review of neurokinin-3 receptor antagonists for the management of vasomotor symptoms of menopause.

Cieri-Hutcherson NE, Marji EK, Hutcherson TC.Menopause. 2024 Apr 1;31(4):342-354. doi: 10.1097/GME.0000000000002328. Epub 2024 Mar 11.PMID: 38471077

Three fezolinetant RCT demonstrated a reduction in VMS frequency/severity, improvement in Menopause-Specific Quality of Life scores, and improvement in sleep quality at weeks 4 and 12 compared with placebo without serious adverse events. ...

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[Sport and menopause].

Maître C.Rev Prat. 2024 Jun;74(6):627-631.PMID: 39011695 French.

SPORT AND MENOPAUSE. The menopause is a physiological period in a woman's life that can be marked by a lot of symptoms impacting her quality of life. ...

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[Hypertension and menopause: physiopathology and impact of the hormonal therapy].

Juillet A, Le Tinier B, Streuli I, Ponte B.Rev Med Suisse. 2024 Sep 11;20(886):1607-1612. doi: 10.53738/REVMED.2024.20.886.1607.PMID: 39262187 Review. French.

In particular, there is an increase in blood pressure during menopause. Menopausal hormonal therapy can be prescribed to women with symptoms of menopause to improve their quality of life. This article reviews the current literature on the pathophysiological m …

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Nutritional interventions in treating menopause-related sleep disturbances: a systematic review.

Polasek D, Santhi N, Alfonso-Miller P, Walshe IH, Haskell-Ramsay CF, Elder GJ.Nutr Rev. 2024 Aug 1;82(8):1087-1110. doi: 10.1093/nutrit/nuad113.PMID: 37695299 Free PMC article.

CONTEXT: Sleep disturbances are a core symptom of menopause, which refers to the permanent cessation of menstrual periods. Nutritional interventions may alleviate menopause-related sleep disturbances, as studies have shown that certain interventions (eg, tart cherry …

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Insights into the vulvar component of the genitourinary syndrome of menopause (GSM).

Cucinella L, Tiranini L, Cassani C, Martini E, Cumetti A, Memoli S, Tedeschi S, Nappi RE.Maturitas. 2024 Aug;186:108006. doi: 10.1016/j.maturitas.2024.108006. Epub 2024 Apr 25.PMID: 38704313 Free article. Review.

This is an essential step in the recognition of different phenotypes of genitourinary syndrome of menopause and in the assessment of the most effective diagnostic and therapeutic algorithm. Menopausal vulvar health deserves more research into tailored non-hormonal a …

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Management of the Vasomotor Symptoms of Menopause: Twofers in Your Clinical Toolbox.

Kling JM, Stuenkel CA, Faubion SS.Mayo Clin Proc. 2024 Jul;99(7):1142-1148. doi: 10.1016/j.mayocp.2024.03.028.PMID: 38960498 Review.

The number of midlife women transitioning into menopause is substantial, with more than 1 million women in the United States entering menopause each year. Vasomotor symptoms (VMS), mood and sleep disturbances, and sexual problems are common during the menopause …

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EMAS position statement: Thyroid disease and menopause.

Mintziori G, Veneti S, Poppe K, Goulis DG, Armeni E, Erel CT, Fistonić I, Hillard T, Hirschberg AL, Meczekalski B, Mendoza N, Mueck AO, Simoncini T, Stute P, van Dijken D, Rees M, Duntas L, Lambrinoudaki I.Maturitas. 2024 Jul;185:107991. doi: 10.1016/j.maturitas.2024.107991. Epub 2024 Apr 24.PMID: 38658290

Aim To construct the first European Menopause and Andropause Society (EMAS) statement on thyroid diseases and menopause. MATERIALS AND METHODS: Literature review and consensus of expert opinion (EMAS executive board members/experts on menopause and thyroid di …

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Impact of Real-life Environmental Exposures on Reproduction: Endocrine-disrupting chemicals, reproductive aging, and menopause.

Inman ZC, Flaws JA.Reproduction. 2024 Oct 3;168(5):e240113. doi: 10.1530/REP-24-0113. Print 2024 Nov 1.PMID: 39222443 Free PMC article. Review.

Menopause naturally occurs at 51 years of age on average, but recent literature suggests that endocrine-disrupting chemicals (EDCs) in our environment can accelerate reproductive aging, causing women to reach menopause at earlier ages. ...EDC exposures have also bee …

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Alcohol use at midlife and in menopause: a narrative review.

Shihab S, Islam N, Kanani D, Marks L, Vegunta S.Maturitas. 2024 Nov;189:108092. doi: 10.1016/j.maturitas.2024.108092. Epub 2024 Aug 22.PMID: 39180900 Review.

Our review delves into the intricate relationship between alcohol use disorder and the menopausal experience. We examine the impact of heightened alcohol consumption on the onset, severity, and burden of menopausal symptoms, particularly vasomotor symptoms. Addition …

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Efficacy and safety of fezolinetant for moderate to severe vasomotor symptoms associated with menopause among women in East Asia: a phase 3 randomized study (MOONLIGHT I).

Ruan X, Bai W, Ren M, Kim T, Lee JY, Chuang FC, Wang PH, He W, Ma X, Miyazaki K, Song N, Wang X, Yu Q.J Int Med Res. 2024 May;52(5):3000605241247684. doi: 10.1177/03000605241247684.PMID: 38818888 Free PMC article. Clinical Trial.

OBJECTIVE: To evaluate the efficacy and safety of fezolinetant for moderate to severe vasomotor symptoms (VMS) associated with menopause in East Asian women. METHODS: In this phase 3, randomized, double-blind study, postmenopausal women with moderate to severe VMS (minimum …

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Design of OASIS 1 and 2: phase 3 clinical trials assessing the efficacy and safety of elinzanetant for the treatment of vasomotor symptoms associated with menopause.

Pinkerton JV, Simon J, Panay N, Seitz C, Parke S, Caetano C, Mellinger U, Haseli Mashhadi N, Haberland C, Atanackovic G, Holz C, Mao G, Morrison M, Nisius S, Schaefers M, Zuurman L.Menopause. 2024 Jun 1;31(6):522-529. doi: 10.1097/GME.0000000000002350. Epub 2024 Apr 3.PMID: 38564691 Clinical Trial.

Key secondary endpoints will assess the onset of action and effects on sleep disturbance and menopause-related quality of life. Primary and key secondary endpoints will be analyzed using a mixed model with repeated measures. ...CONCLUSIONS: The OASIS 1 and 2 pivotal phase …

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The need for biopsychosocial menopause care: a narrative review.

Evans S, Van Niekerk L, Orellana L, O'Shea M, Druitt MI, Jones S, Corrigan S, Heggen C, Arashiro Z, Baber R, Satyen L, Skvarc D, Mikocka-Walus A.Menopause. 2024 Dec 1;31(12):1090-1096. doi: 10.1097/GME.0000000000002441. Epub 2024 Oct 29.PMID: 39470610 Review.

IMPORTANCE AND OBJECTIVE: Menopause is a reproductive transition affecting half the world's population. Stigma and limited availability of evidence-based treatments that support biopsychosocial well-being mean that this life stage is often associated with challenging sympt …

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Menopause and brain fog: how to counsel and treat midlife women.

Maki PM, Jaff NG.Menopause. 2024 Jul 1;31(7):647-649. doi: 10.1097/GME.0000000000002382. Epub 2024 Jun 17.PMID: 38888619

Brain fog, referring to menopause-related subjective cognitive difficulties, is common in midlife women. Longitudinal studies find small but reliable declines in objective memory performance as women transition into perimenopause, and these are not explained by advancing a …

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Fezolinetant impact on health-related quality of life for vasomotor symptoms due to the menopause: Pooled data from SKYLIGHT 1 and SKYLIGHT 2 randomised controlled trials.

Cano A, Nappi RE, Santoro N, Stute P, Blogg M, English ML, Morga A, Scrine L, Siddiqui E, Ottery FD.BJOG. 2024 Aug;131(9):1296-1305. doi: 10.1111/1471-0528.17773. Epub 2024 Feb 6.PMID: 38320967 Free article. Clinical Trial.

MAIN OUTCOME MEASURES: Mean changes from baseline to weeks 4 and 12 on Menopause-Specific Quality of Life (MENQoL) total and domain scores, Work Productivity and Activity Impairment questionnaire specific to VMS (WPAI-VMS) domain scores, Patient Global Impression of Change …

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Neuroendocrine mechanisms of mood disorders during menopause transition: A narrative review and future perspectives.

Fidecicchi T, Giannini A, Chedraui P, Luisi S, Battipaglia C, Genazzani AR, Genazzani AD, Simoncini T.Maturitas. 2024 Oct;188:108087. doi: 10.1016/j.maturitas.2024.108087. Epub 2024 Aug 2.PMID: 39111089 Free article. Review.

The menopause transition is an important period in a woman's life, during which she is at an increased risk of mood disorders. Estrogen and progesterone fluctuations during the menopausal transition and very low levels of estradiol after menopause have a prof …

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Menopause as a window of opportunity: the benefits of designing more effective theory-driven behaviour change interventions to promote healthier lifestyle choices at midlife.

Simpson EEA, Doherty J, Timlin D.Proc Nutr Soc. 2024 May;83(2):120-129. doi: 10.1017/S0029665123004810. Epub 2023 Nov 13.PMID: 37955168 Review.

Menopause represents a window of opportunity to promote health, and to support women to make healthier lifestyle choices, part of the National Institute for Clinical Excellence guidelines for menopause management. ...This review paper will explore the impact of m …

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Management of menopause in women living with HIV - A comparative guideline review.

Scofield D, Moseholm E, Aebi-Popp K, Hachfeld A; Women Against Viruses in Europe (WAVE), European AIDS Clinical Society. Electronic address: wavesecretariat@eacssociety.org.Maturitas. 2024 May;183:107937. doi: 10.1016/j.maturitas.2024.107937. Epub 2024 Feb 9.PMID: 38367364 Free article. Review.

The focus is on three key areas: the diagnosis of menopause, and the assessment and treatment of menopausal symptoms. Additionally, the review evaluates the usage and characteristics of menopausal symptom assessment scales known to have been used in studies i …

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Hormone replacement therapy in surgical menopause after gynecological malignancies.

Tomić Naglić D, Mandić A, Zirojević M, Vuković N, Pejaković S, Manojlovic M, Bajkin I, Ičin T, Janičić S, Stokić E.Biomol Biomed. 2025 Mar 7;25(4):751-760. doi: 10.17305/bb.2024.11220.PMID: 39556012 Free article. Review.

Unlike natural menopause, surgical menopause occurs abruptly, without an adjustment period, and is associated with a notably higher risk of fractures, arthritis, cognitive decline, dementia, Parkinson's disease, and various metabolic disorders affecting glucose and …

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Sexual health and wellbeing and the menopause: An EMAS clinical guide.

Paschou SA, Athanasiadou KI, Hafford-Letchfield T, Hinchliff S, Mauskar M, Rees M, Simon JA, Armeni E, Erel CT, Fistonic I, Hillard T, Hirschberg AL, Meczekalski B, Mendoza N, Mueck AO, Simoncini T, Stute P, van Dijken D, Lambrinoudaki I.Maturitas. 2024 Nov;189:108055. doi: 10.1016/j.maturitas.2024.108055. Epub 2024 Sep 2.PMID: 39226624 Review.

AIM: To provide an evidence-based clinical guide for the assessment and management of sexual problems at the menopause and beyond. MATERIALS AND METHODS: Review of the literature and consensus of expert opinion. ...To conclude, taking a sexual history should be incorporate …

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Weight Gain in Midlife Women.

Hurtado MD, Saadedine M, Kapoor E, Shufelt CL, Faubion SS.Curr Obes Rep. 2024 Jun;13(2):352-363. doi: 10.1007/s13679-024-00555-2. Epub 2024 Feb 28.PMID: 38416337 Free PMC article. Review.

RECENT FINDINGS: Aging-related changes such as decreased energy expenditure and physical activity are important culprits for weight gain in midlife women. The hormonal changes of menopause also influence body adiposity distribution and increase central adiposity. These bod …

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Navigating the Proteomic Landscape of Menopause: A Review.

Katamesh BE, Futela P, Vincent A, Thilagar B, Whipple M, Hassan AR, Abuelazm M, Nanda S, Anstine C, Singla A.Medicina (Kaunas). 2024 Sep 9;60(9):1473. doi: 10.3390/medicina60091473.PMID: 39336514 Free PMC article. Review.

However, no comprehensive summary of proteomics and menopausal health exists. Our objective was to summarize proteomic profiles associated with diseases and disorders in peri- and postmenopausal women. ...

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A review of menopause in transgender and gender diverse individuals.

Kelley CE, Ariel D.Curr Opin Obstet Gynecol. 2025 Apr 1;37(2):83-96. doi: 10.1097/GCO.0000000000001013. Epub 2025 Feb 25.PMID: 39970047 Review.

RECENT FINDINGS: Research on menopause in TGD individuals is lacking, without guidelines to support clinical management. ...SUMMARY: By drawing on the shared principles of cisgender menopausal hormone therapy and gender-affirming hormone therapy, providers are well …

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The Impact of Menopause on the Mental Health of Women With an Intellectual Disability: A Scoping Review.

Corrigan S, McCarron M, McCallion P, Burke É.J Appl Res Intellect Disabil. 2025 Jan;38(1):e70017. doi: 10.1111/jar.70017.PMID: 39871807 Free PMC article. Review.

BACKGROUND: Negative mental health implications of menopause found in the general population, combined with high rates of mental health conditions found in women with intellectual disabilities, provide rationale to examine the existing literature to determine the impact of …

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Fezolinetant: a novel nonhormonal therapy for vasomotor symptoms due to menopause.

Roberts MZ, Andrus MR.Expert Opin Pharmacother. 2024 Jun;25(9):1131-1136. doi: 10.1080/14656566.2024.2375039. Epub 2024 Jul 8.PMID: 38953697 Review.

INTRODUCTION: During menopause, the majority of women experience vasomotor symptoms which may lead to several untoward effects and negatively impact quality of life. Fezolinetant, a novel agent directly targeting the underlying pathophysiology of menopause-associate …

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Evolutionary Perspectives, Comparative Approaches, and the Lived Experience of Menopause.

Sievert LL.Am J Biol Anthropol. 2025 Feb;186(2):e70012. doi: 10.1002/ajpa.70012.PMID: 39949285 Review.

The purpose of this synthesis is to review age at menopause, symptom experience at midlife, and the evolution of menopause in a way that is helpful for biological anthropologists who are interested in the study of this challenging time of life. The synthesis begins …

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Menopause in a globalized world - A systematic literature review focussing on the challenge of health problems associated with menopausal transition among women with a migration background.

Kirchengast S.Maturitas. 2024 Sep;187:108045. doi: 10.1016/j.maturitas.2024.108045. Epub 2024 Jun 6.PMID: 38870679 Free article. Review.

To enable personalized treatment, studies on menopausal transition in women with a migration background are required. The present review shows that studies on menopausal women with a migration background have been conducted primarily in classic immigration countries …

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Lensen S, Paramanandam VS, Gabes M, Kann G, Donhauser T, Waters NF, Li AD, Peate M, Susanto NS, Caughey LE, Rangoonwal F, Liu J, Condron P, Anagnostis P, Archer DF, Avis NE, Bell RJ, Carpenter JS, Chedraui P, Christmas M, Davies M, Hillard T, Hunter MS, Iliodromiti S, Jaff NG, Jaisamrarn U, Joffe H, Khandelwal S, Kiesel L, Maki PM, Mishra GD, Nappi RE, Panay N, Pines A, Roberts H, Rozenberg S, Rueda C, Shifren J, Simon JA, Simpson P, Siregar MFG, Stute P, Garcia JT, Vincent AJ, Wolfman W, Hickey M.Menopause. 2024 Jul 1;31(7):582-590. doi: 10.1097/GME.0000000000002370. Epub 2024 Apr 30.PMID: 38688464

OBJECTIVE: The aim of the study is to identify suitable definitions and patient-reported outcome measures (PROMs) to assess each of the six core outcomes previously identified through the COMMA (Core Outcomes in Menopause) global consensus process relating to vasomotor sym …

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Factors affecting age at menopause and their relationship with ovarian reserve: a comprehensive review.

La Marca A, Diamanti M.Eur J Contracept Reprod Health Care. 2024 Oct;29(5):245-255. doi: 10.1080/13625187.2024.2375281. Epub 2024 Jul 15.PMID: 39007753 Review.

The following keywords were used to generate the list of citations: 'menopause', 'ovarian reserve' 'oocytes quality and quantity', 'ovarian ageing'. RESULTS: Menopause is the final step in the process of ovarian ageing and is influenced by the oocyte pool at birth. …

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BMI and breast cancer risk around age at menopause.

Von Holle A, Adami HO, Baglietto L, Berrington de Gonzalez A, Bertrand KA, Blot W, Chen Y, DeHart JC, Dossus L, Eliassen AH, Fournier A, Garcia-Closas M, Giles G, Guevara M, Hankinson SE, Heath A, Jones ME, Joshu CE, Kaaks R, Kirsh VA, Kitahara CM, Koh WP, Linet MS, Park HL, Masala G, Mellemkjaer L, Milne RL, O'Brien KM, Palmer JR, Riboli E, Rohan TE, Shrubsole MJ, Sund M, Tamimi R, Tin Tin S, Visvanathan K, Vermeulen RC, Weiderpass E, Willett WC, Yuan JM, Zeleniuch-Jacquotte A, Nichols HB, Sandler DP, Swerdlow AJ, Schoemaker MJ, Weinberg CR.Cancer Epidemiol. 2024 Apr;89:102545. doi: 10.1016/j.canep.2024.102545. Epub 2024 Feb 19.PMID: 38377945

BACKGROUND: A high body mass index (BMI, kg/m(2)) is associated with decreased risk of breast cancer before menopause, but increased risk after menopause. Exactly when this reversal occurs in relation to menopause is unclear. ...Sensitivity analyses included …

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Is it possible that menopause is associated with telomere length? Findings of an integrative review.

Bem MMS, Paraizo-Horvath CMS, Freitas PS, Brito TRP.Climacteric. 2024 Dec;27(6):521-525. doi: 10.1080/13697137.2024.2376193. Epub 2024 Jul 18.PMID: 39023108 Review.

RESULTS: The findings of these studies indicate that older age for menopause and longer reproductive life (difference between age at menopause and menarche) are associated with longer telomeres, that is, with longevity. CONCLUSION: The relationship between menopa …

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The Effect of Menopause on Vaginal Tissue Mechanics: A Brief Review.

Gimenez C, Alperin M, De Vita R.J Biomech Eng. 2024 Jun 1;146(6):060903. doi: 10.1115/1.4063101.PMID: 37542707 Review.

Often called "the change of life," menopause affects every part of a woman's body. As the sex hormones decrease, the reproductive organs experience the most remarkable changes, with the vagina becoming thinner, drier, and less elastic. ...The purpose of this article is to …

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Oral Health Care Among Women in Perimenopause or Menopause: An Integrative Review.

Thomas N, Peters K, Reilly KO, Sousa MS, George A.J Midwifery Womens Health. 2025 Jan-Feb;70(1):17-31. doi: 10.1111/jmwh.13668. Epub 2024 Jul 24.PMID: 39045880 Free PMC article. Review.

INTRODUCTION: Women in menopause are at a higher risk of developing oral health problems, affecting their overall quality of life. ...DISCUSSION: Women in perimenopause or menopause have limited oral health knowledge and unmet oral health needs. Appropriate guidelin …

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Exploring the effects of estrogen deficiency and aging on organismal homeostasis during menopause.

Camon C, Garratt M, Correa SM.Nat Aging. 2024 Dec;4(12):1731-1744. doi: 10.1038/s43587-024-00767-0. Epub 2024 Dec 13.PMID: 39672893 Free PMC article. Review.

However, it remains unclear whether age-associated changes in homeostasis are dependent on reduced estrogen signaling during menopause. Although menopausal hormone therapies containing estrogens can alleviate symptoms, concerns about the risks involved have contribu …

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The effectiveness of psychosocial interventions on non-physiological symptoms of menopause: A systematic review and meta-analysis.

Spector A, Li Z, He L, Badawy Y, Desai R.J Affect Disord. 2024 May 1;352:460-472. doi: 10.1016/j.jad.2024.02.048. Epub 2024 Feb 15.PMID: 38364979 Free article. Review.

BACKGROUND: Menopause, a crucial transitioning stage for women, can significantly impact mood and wellbeing. We aimed to evaluate the effectiveness of psychosocial interventions on non-physiological symptoms of menopause (depression, anxiety, cognition, and quality …

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Incremental Cardiovascular Risk of Menopause in Women with Psoriasis, Psoriatic Arthritis or Spondyloarthritis?

Vegt DE, Popa-Diaconu DA, Mulder MLM, van Leuven SI, van der Horst-Bruinsma IE.Curr Rheumatol Rep. 2024 Dec 6;27(1):6. doi: 10.1007/s11926-024-01169-2.PMID: 39641871 Review.

RECENT FINDINGS: Literature shows that psoriasis, PsA, SpA and menopause itself cause higher CVD risks and higher CVD prevalence. This is predominantly explained by the increase of chronic systemic inflammation. No existing literature conclusively demonstrates or studies s …

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The impact of physical activity and exercise interventions on symptoms for women experiencing menopause: overview of reviews.

Money A, MacKenzie A, Norman G, Eost-Telling C, Harris D, McDermott J, Todd C.BMC Womens Health. 2024 Jul 13;24(1):399. doi: 10.1186/s12905-024-03243-4.PMID: 39003439 Free PMC article. Review.

BACKGROUND: Women experiencing problematic menopausal symptoms report lower health-related quality of life and greater healthcare use than women without symptoms. ...AIM: This overview assesses effectiveness of physical activity and exercise interventions targeting women e …

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Unveiling FOXO3's metabolic contribution to menopause and Alzheimer's disease.

O'Mahony C, Hidalgo-Lanussa O, Barreto GE.Exp Gerontol. 2025 Feb;200:112679. doi: 10.1016/j.exger.2025.112679. Epub 2025 Jan 9.PMID: 39778695 Free article. Review.

We propose that FOXO3 plays a key role in the intersection of menopause and AD, given its dysregulation in both AD patients and postmenopausal women, modulating cellular metabolism through interactions with the AMPK/AKT/PI3K pathways. ...This review aims to open a discussi …

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Age at menopause and cognitive function and decline among middle-aged and older women in the China Health and Retirement Longitudinal Study, 2011-2018.

Guo M, Wu Y, Gross AL, Karvonen-Gutierrez C, Kobayashi LC.Alzheimers Dement. 2025 Feb;21(2):e14580. doi: 10.1002/alz.14580.PMID: 39936226 Free PMC article.

Although the rate of cognitive decline did not differ significantly across menopause age groups, late menopause showed a trend toward faster decline. DISCUSSION: Cognitive health interventions should consider extreme menopausal age as a risk factor. HIGHLIGHT …

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Association of reproductive lifespan and age at menopause with depression: Data from NHANES 2005-2018.

Wu Q, Yan Y, La R, Zhang X, Lu L, Xie R, Xue Y, Lin C, Xu W, Xu J, Huang L.J Affect Disord. 2024 Jul 1;356:519-527. doi: 10.1016/j.jad.2024.04.077. Epub 2024 Apr 22.PMID: 38657760

Reproductive lifespan was defined as years from age at menarche to age at menopause. Depression was assessed using the Patient Health Questionnaire-9 (PHQ-9). Multivariable logistic regression models were used to explore the relationship between the association of reproduc …

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Transfer of preclinical study data on the influence of cimicifuga racemosaon functional changes in the hippocampus during menopause.

Stute P, Henneicke-von Zepelin HH, Nicken P.Gynecol Endocrinol. 2024 Dec;40(1):2360066. doi: 10.1080/09513590.2024.2360066. Epub 2024 Jun 4.PMID: 38833172 Free article. Review.

Menopausal transition in women involves complex neurobiochemical changes linked to ovarian dysfunction, resulting in symptoms like vasomotor symptoms (VMS), sleep disturbances, anxiety, and cognitive impairments. ...A preclinical pilot study exploring iCR's effects on gene …

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Women's experiences and expectations during the menopause transition: a systematic qualitative narrative review.

Wood K, McCarthy S, Pitt H, Randle M, Thomas SL.Health Promot Int. 2025 Jan 17;40(1):daaf005. doi: 10.1093/heapro/daaf005.PMID: 40036278 Free PMC article. Review.

There is an increased research focus on the menopause transition. However, this literature is still largely focused on quantitatively surveying women about their menopause symptoms, with less qualitative focus on women's lived experiences of menopause. This i …

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Follicle-stimulating hormone: More than a marker for menopause: FSH as a frontier for women's mental health.

Spicer J, Malaspina D, Blank SV, Goosens KA.Psychiatry Res. 2025 Mar;345:116239. doi: 10.1016/j.psychres.2024.116239. Epub 2024 Oct 28.PMID: 39892305 Review.

The average current life expectancy entails that women will spend over one-third of their lives in menopause. Follicle-stimulating hormone (FSH) levels in women begin to increase roughly six years before the final menstrual period, reaching a menopausal plateau that …

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Paramanandam VS, Lensen S, Gabes M, Kann G, Donhauser T, Waters NF, Li AD, Peate M, Susanto NS, Caughey LE, Rangoonwal F, Liu J, Condron P, Obalowu IA, Archer DF, Bell RJ, Christmas M, Davies M, Davis SR, Giblin K, Iliodromiti S, Jaisamrarn U, Khandelwal S, Kiesel L, Aggarwal N, Mitchell CM, Mishra GD, Nappi RE, Panay N, Roberts H, Rozenberg S, Shifren J, Simon JA, Stute P, Vincent AJ, Wolfman W, Hickey M.Menopause. 2024 Jul 1;31(7):591-599. doi: 10.1097/GME.0000000000002369. Epub 2024 May 14.PMID: 38743907

OBJECTIVE: The aim of the study is to identify appropriate definitions and patient-reported outcome measures (PROMs) for each of the eight core outcomes previously selected for genitourinary symptoms associated with menopause: pain with sex, vulvovaginal dryness, vulvovagi …

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Ovarian tissue cryopreservation and transplantation as a natural means to delay menopause.

Sacinti KG, Sadat R, Ozkavukcu S, Sonmezer M, Sonmezer M.Arch Gynecol Obstet. 2024 Nov;310(5):2305-2313. doi: 10.1007/s00404-024-07752-3. Epub 2024 Sep 28.PMID: 39340555 Review.

There is a growing interest in utilizing OTCT to delay menopause and alleviate associated health issues. Menopausal transition affects women globally, leading to symptoms and long- term health risks. ...This review highlights advancements and the feasibility of OTCT …

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Early menopause and hormone therapy as determinants for lung health outcomes: a secondary analysis using the PLCO trial.

Gai X, Feng Y, Flores TM, Kang H, Yu H, Leslie KK, Zhu Y, Doherty JA, Guo Y, Belinsky SA, Cook LS, Leng S.Thorax. 2024 Sep 18;79(10):961-969. doi: 10.1136/thorax-2023-220956.PMID: 38871464 Clinical Trial.

RATIONALE: Early natural menopause (early-M; <45 years of age) increases the risk of lung morbidities and mortalities in smokers. ...CONCLUSIONS: Smokers with early-M should be targeted for smoking cessation and LC screening regardless of menopause types. MHT use …

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Understanding Why Homeopathic Medicines are Used for Menopause: Searching for Insights into Neuroendocrine Features.

Macías-Cortés E.Homeopathy. 2024 May;113(2):54-66. doi: 10.1055/s-0043-1769734. Epub 2023 Jul 3.PMID: 37399836 Free article. Review.

METHODS: An extensive literature search for the pathophysiologic events of menopause and depression, as well as for the current evidence for HMs in menopause and depression, was performed. ...CONCLUSION: Based on all the pathophysiologic events of menopause a …

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Is it time to revisit the recommendations for initiation of menopausal hormone therapy?

Taylor S, Davis SR.Lancet Diabetes Endocrinol. 2025 Jan;13(1):69-74. doi: 10.1016/S2213-8587(24)00270-5. Epub 2024 Oct 14.PMID: 39419045 Review.

Findings from the Women's Health Initiative studies led to menopausal hormone therapy (MHT) guidelines generally recommending the initiation of MHT be limited to women within 10 years of their menopause or before the age of 60 years. This recommendation has led to w …

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Relationship between early age at menarche, older age at menopause and subtypes of breast cancer: a scoping review.

Lopes LCP, Medeiros GA, Gualberto IJN, Gut TB, Ferrazini RVS, Negrato CA.Rev Bras Ginecol Obstet. 2024 Sep 6;46:e-rbgo50. doi: 10.61622/rbgo/2024rbgo50. eCollection 2024.PMID: 39380584 Free PMC article.

OBJECTIVE: To determine the relationship between early age at menarche, late age at menopause with specific subtypes of breast cancer (BC). METHODS: A literature search was conducted in Embase, Lilacs, PubMed, Scopus, and Scielo databases, following the Joanna Briggs Insti …

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The Pathophysiology, Prognosis and Treatment of Hypertension in Females from Pregnancy to Post-menopause: A Review.

Li S, Tan I, Atkins E, Schutte AE, Gnanenthiran SR.Curr Heart Fail Rep. 2024 Aug;21(4):322-336. doi: 10.1007/s11897-024-00672-y. Epub 2024 Jun 11.PMID: 38861130 Free PMC article. Review.

PURPOSE OF REVIEW: We summarise the physiological changes and risk factors for hypertension in females, potential sex-specific management approaches, and long-term prognosis. KEY FINDINGS: Pregnancy and menopause are two key phases of the life cycle where females undergo s …

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Menopause and the workplace: consensus recommendations from The Menopause Society.

Menopause Society Menopause and the Workplace Advisory Panel.Menopause. 2024 Sep 1;31(9):741-749. doi: 10.1097/GME.0000000000002415.PMID: 39186451

Although menopause is a universal and natural life transition, the symptom experience is highly variable among women. ...Further, the relationship between menopause symptoms and work may be bidirectional, with certain aspects of the work environment being linked wit …

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New Horizons in Menopause, Menopausal Hormone Therapy, and Alzheimer's Disease: Current Insights and Future Directions.

Mosconi L, Nerattini M, Williams S, Fink M.J Clin Endocrinol Metab. 2025 Mar 17;110(4):911-921. doi: 10.1210/clinem/dgaf026.PMID: 39815764 Review.

Accumulating evidence suggests that the effects of menopausal hormone therapy (MHT) on risk of Alzheimer disease (AD) and all-cause dementia are influenced by timing of initiation relative to age, time-since-menopause, and the type of formulation. ...

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Development of the Menopause Perception Scale.

Abay H, Altun E, Kaplan S.Menopause. 2024 Sep 1;31(9):818-827. doi: 10.1097/GME.0000000000002398. Epub 2024 Jul 20.PMID: 39042024

OBJECTIVE: How women perceive menopause depends on how well they go through that period of time. However, there is no measure that can be used to assess how women perceive menopause. ...Furthermore, the MPS was significantly correlated with the Menopause Atti …

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The influence of menopause on multiple sclerosis.

Simonsen CS, Flemmen HØ, Broch L, Myklebust H, Berg-Hansen P, Brunborg C, Celius EG.Eur J Neurol. 2025 Jan;32(1):e16566. doi: 10.1111/ene.16566. Epub 2024 Nov 27.PMID: 39601490 Free PMC article.

INTRODUCTION: One third of the multiple sclerosis (MS) population consists of peri- or postmenopausal women. Many symptoms of menopause overlap those of MS. Some studies show increased speed of disability progression after menopause, while others indicate an unalter …

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Imaging and molecular features of adenomyosis after menopause.

Vannuccini S, Gabbrielli S, Castiglione F, Nardi E, Rossi M, Orlandi G, Wu E, Bertoli F, Miele V, Donati C, Petraglia F.Maturitas. 2024 Jul;185:107996. doi: 10.1016/j.maturitas.2024.107996. Epub 2024 Apr 12.PMID: 38657487 Free article.

Molecular characterization of postmenopausal versus pre-menopausal adenomyosis samples. RESULTS: According to TVUS and MRI, adenomyosis was identified in 49 patients (10.4 %). ...By comparing the results with those from pre-menopausal samples, the expression of alph …

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Managing menopause in an irradiated pelvis - uncharted territory.

Darnborough S.Post Reprod Health. 2024 Jun;30(2):127-134. doi: 10.1177/20533691241235060. Epub 2024 Mar 8.PMID: 38458182

Radiotherapy to the pelvis causes lasting side-effects collectively referred to as pelvic radiation disease (PRD), including bowel, bladder, sexual dysfunction, vaginal and cervical stenoses, and menopause. There is growing interest in management of menopause in can …

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Menopause-Associated Changes in Mandibular Bone Microarchitecture Are Site-Specific.

Levit M, Finn T, Sachadava S, Matsumura S, Shah J, Cantos A, Yin MT, Wadhwa S.J Oral Maxillofac Surg. 2024 Apr;82(4):485-493. doi: 10.1016/j.joms.2024.01.015. Epub 2024 Feb 1.PMID: 38341183

INDEPENDENT VARIABLE: The predictor variables are menopausal status (before or after menopause) and mandibular region of interest (condyle/basal bone). ...There were no significant differences in the basal bone microarchitectural parameters between the menopausal …

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Changes in cardiovascular arachidonic acid metabolism in experimental models of menopause and implications on postmenopausal cardiac hypertrophy.

Gerges SH, El-Kadi AOS.Prostaglandins Other Lipid Mediat. 2024 Aug;173:106851. doi: 10.1016/j.prostaglandins.2024.106851. Epub 2024 May 11.PMID: 38740361 Free article. Review.

Menopause is a normal stage in the human female aging process characterized by the cessation of menstruation and the ovarian production of estrogen and progesterone hormones. ...It is possible that these changes might play a role in the increased risk of cardiac hypertroph …

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Body composition, physical activity, and menopause symptoms: how do they relate?

Moore SR, Cabre HE, Smith-Ryan AE.Menopause. 2024 Apr 1;31(4):336-341. doi: 10.1097/GME.0000000000002334. Epub 2024 Mar 5.PMID: 38442308

TMSs were quantified using The North American Menopause Society Questionnaire. RESULTS: Significant associations were observed between TMSs and %BF ( r = 0.464, P < 0.001) and VIG ( r = -0.245, P = 0.038). ...CONCLUSIONS: %BF predicted nearly half of the variance in PER

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Possible association between subclinical hypothyroidism and age at menopause in Colombian women.

Monterrosa-Castro Á, Monterrosa-Blanco A, Sánchez-Zarza S.Gynecol Endocrinol. 2024 Dec;40(1):2334798. doi: 10.1080/09513590.2024.2334798. Epub 2024 Apr 8.PMID: 38590105 Free article.

OBJECTIVE: To evaluate the association between subclinical hypothyroidism with early menopause, premature menopause, and last menstrual bleeding before the natural age of menopause. ...Groups were formed according to last menstrual episode: 45 [Natural age at …

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A systematic review and meta-analysis investigating differences in chronic inflammation and adiposity before and after menopause.

Pernoud LE, Gardiner PA, Fraser SD, Dillon-Rossiter K, Dean MM, Schaumberg MA.Maturitas. 2024 Dec;190:108119. doi: 10.1016/j.maturitas.2024.108119. Epub 2024 Sep 26.PMID: 39332331

BACKGROUND: Menopause represents a pivotal physiological transition characterized by hormonal fluctuations and an augmented susceptibility to chronic diseases. The relationship between menopause and heightened disease risk may be attributed in part to alterations in …

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Menopause and the role of physical activity - The views and knowledge of women aged 40-65.

Wasley D, Gailey S.Post Reprod Health. 2024 Jun;30(2):77-84. doi: 10.1177/20533691241235273. Epub 2024 Feb 23.PMID: 38393976 Free PMC article.

A high proportion were active and felt that physical activity can help manage symptoms and impact long-term health consequences of menopause. Menopause education strategies for women, healthcare professionals and others need to be improved. ...Physical activity was …

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What are the health needs of women with female genital mutilation going through menopause?

Kamal A, Kamara S, Khasriya R, Elneil S, Newson L, Reisel D.Maturitas. 2024 Sep;187:108058. doi: 10.1016/j.maturitas.2024.108058. Epub 2024 Jun 22.PMID: 38959753 Free article. Review.

There has, though, been little, if any, focus on how women with female genital mutilation experience menopause. A literature search did not return any published research on the topic and there are currently no clinical guidelines for managing the menopause in women …

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Addressing menopause symptoms in the primary care setting: opportunity to bridge care delivery gaps.

Bevry ML, Stogdill ER, Lea CM, Taylor KR, Lovaas AM, Bailey KJ, Mara KC, Dierkhising RA, Chaudhry R, Faubion SS, Kapoor E.Menopause. 2024 Dec 1;31(12):1044-1048. doi: 10.1097/GME.0000000000002439. Epub 2024 Oct 1.PMID: 39352126

OBJECTIVE: Menopause symptoms affect quality of life and financial well-being but are often unaddressed in primary care clinics. Therefore, we evaluated the extent of menopause symptom documentation in electronic health records (EHRs) by primary health care professi …

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Age at Menopause and Development of Type 2 Diabetes in Korea.

Ko BJ, Jung JH, Han K, Nam GE.JAMA Netw Open. 2025 Jan 2;8(1):e2455388. doi: 10.1001/jamanetworkopen.2024.55388.PMID: 39836420 Free PMC article.

IMPORTANCE: There is limited evidence regarding the association between age at menopause and incident type 2 diabetes (T2D). OBJECTIVE: To investigate whether age at menopause and premature menopause are associated with T2D incidence in postmenopausal Korean …

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Evolutionary Perspectives, Comparative Approaches, and the Lived Experience of Menopause.

Sievert LL.Am J Biol Anthropol. 2024 Dec;186 Suppl 78:e25067. doi: 10.1002/ajpa.25067.PMID: 40071785 Review.

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Menopause and metabolic syndrome: anthropometric, lipid, and dietary profiles.

Gonçalves VBS, Lima SMRR.Rev Assoc Med Bras (1992). 2024 Jul 19;70(6):e20231571. doi: 10.1590/1806-9282.20231571. eCollection 2024.PMID: 39045954 Free PMC article.

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Multiomic profiling reveals timing of menopause predicts prefrontal cortex aging and cognitive function.

Gunter-Rahman F, Adams CD, Raju RM, Zhang Y, Lee EA, Messerlian C.Aging Cell. 2025 Feb;24(2):e14395. doi: 10.1111/acel.14395. Epub 2024 Nov 5.PMID: 39501567 Free PMC article.

Age at menopause (AAM) is positively correlated with cognitive function and negatively correlated with pre-frontal cortex aging acceleration (calculated as estimated biological age from DNA methylation minus chronological age). ...Together, our data suggest that AAM is pre …

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A quality assessment and systematic review of clinical practice guidelines on hormone replacement therapy for menopause using the AGREE II instrument.

Roman MP, Ciortea R, Doumouchtsis SK, Din R, Măluţan AM, Bucuri CE, Căşeriu EA, Ormindean CM, Nati ID, Suciu VE, Mihu D.Eur J Obstet Gynecol Reprod Biol. 2024 Dec;303:294-301. doi: 10.1016/j.ejogrb.2024.10.046. Epub 2024 Nov 2.PMID: 39515127 Free article. Review.

Clinical Practice Guidelines (CPGs) have an indispensable role in guiding the selection of treatments for menopause. Variations in guidelines can impact treatments and health outcomes. The aim of this study was to assess CPGs on hormone replacement therapy (HRT) for men …

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Menopause in adult women with human papillomavirus: health-related quality of life and determinants.

Calvo-Torres J, Rejas J, Ramírez-Mena M, González-Granados C, Bradbury M, Del Pino M, Procas B, Rubio-Arroyo M, Presa-Lorite J, Gippini I, Fasero M, Fiol G, Romero P, Cohen A, Coronado PJ; HPV-QoL Study group.Menopause. 2024 Sep 1;31(9):809-817. doi: 10.1097/GME.0000000000002395. Epub 2024 Aug 5.PMID: 39186453

OBJECTIVE: Human papillomavirus (HPV) infection and menopause entail a considerable impairment in health-related quality of life (HRQoL). The objective of the present study was to analyze the impact of the menopause status on HRQoL in women with HPV infection. ...CO …

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[Weight gain during menopause: physiology and practical implications].

Correia JC, Mavromati M, Pataky Z.Rev Med Suisse. 2024 Mar 20;20(866):580-583. doi: 10.53738/REVMED.2024.20.866.580.PMID: 38506458 French.

Fluctuations in sex hormones at different stages of reproductive life, such as the menopausal transition, have been suggested as players in weight regulation. Indeed, the transition from a predominantly estrogenic state to an androgenic state characteristic of the menop …

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The Effect of Yoga on Menopause Symptoms: A Randomized Controlled Trial.

Abiç A, Yilmaz Vefikuluçay D.Holist Nurs Pract. 2024 May-Jun 01;38(3):138-147. doi: 10.1097/HNP.0000000000000646. Epub 2024 May 6.PMID: 38709129 Clinical Trial.

The research was conducted as a randomized controlled study with the aim of determining the effect of yoga on menopause symptoms. Menopausal women between the ages of 40 and 60 years were included in the research. There were 31 menopausal women in each of 2 g …