Recent publications in Prostate Health

Prostate Risk and Monitoring During Testosterone Replacement Therapy.

Bhasin S, Thompson IM.J Clin Endocrinol Metab. 2024 Jul 12;109(8):1975-1983. doi: 10.1210/clinem/dgae334.PMID: 38753865 Review.

Among men with hypogonadism, carefully screened to exclude those at high risk of prostate cancer, the incidences of high-grade or any prostate cancer, acute urinary retention, surgical procedure for benign prostatic hyperplasia, prostate biopsy, or new …

Targeted biopsy of the prostate.

Schroeder DW, Foster BR, Young DJ, Coakley FV.Abdom Radiol (NY). 2025 Jan;50(1):261-271. doi: 10.1007/s00261-024-04452-z. Epub 2024 Jul 8.PMID: 38976055 Review.

Diagnostic multiparametric MRI of the prostate has steadily evolved over the last three decades and can now reliably depict the dominant tumor in most men with prostate cancer. ...These advances are leading to a sea change in the approach to prostate cancer d …

Integrated single-cell analysis defines the epigenetic basis of castration-resistant prostate luminal cells.

Kirk JS, Wang J, Long M, Rosario S, Tracz A, Ji Y, Kumar R, Liu X, Jamroze A, Singh PK, Puzanov I, Chatta G, Cheng Q, Huang J, Wrana JL, Lovell J, Yu H, Liu S, Shen MM, Liu T, Tang DG.Cell Stem Cell. 2024 Aug 1;31(8):1203-1221.e7. doi: 10.1016/j.stem.2024.05.008. Epub 2024 Jun 14.PMID: 38878775

Understanding prostate response to castration and androgen receptor signaling inhibitors (ARSI) is critical to improving long-term prostate cancer (PCa) patient survival. Here, we use a multi-omics approach on 229,794 single cells to create a mouse single-cell refer …

Prostate and gut: Any relationship? A narrative review on the available evidence and putative mechanisms.

Romano L, Napolitano L, Crocetto F, Sciorio C, Sio M, Miranda A, Romano M, Priadko K.Prostate. 2024 May;84(6):513-524. doi: 10.1002/pros.24675. Epub 2024 Feb 14.PMID: 38353479 Review.

RESULTS: Gut microbiota (GM) and its metabolites are capable of modifying host androgen level, as well as prostate cancer (PCa) therapy response. Moreover, patients with inflammatory bowel disease have higher rates of prostatitis-like symptoms and a potential risk o …

AI-accelerated prostate MRI: a systematic review.

Reinhardt C, Briody H, MacMahon PJ.Br J Radiol. 2024 Jun 18;97(1159):1234-1242. doi: 10.1093/bjr/tqae093.PMID: 38718224

The emergence of AI-acceleration in prostate MRI offers promise to mitigate these challenges. METHODS: A systematic review of studies looking at AI-accelerated prostate MRI was conducted, with a focus on acquisition time along with various qualitative and quantitati …

Optimising prostate biopsies and imaging for the future-a review.

Chan K, Ghani DAM, Teoh J, Brodie A, Gan C, Foley C, Dasgupta P, Vasdev N.Urol Oncol. 2024 Dec;42(12):421-428. doi: 10.1016/j.urolonc.2024.08.019. Epub 2024 Sep 19.PMID: 39299895 Review.

Conventionally, transrectal ultrasound guided prostate biopsy (TRUS-Bx) was the main technique used for the diagnosis of prostate cancer since it was first described in 1989 [1]. ...Our narrative review provides an overview on prostate biopsy techniques and a …

Prostate Imaging Quality System Version 2 - A Practical Guide.

Knott EA, Ward RD, Costa DN, Giganti F, Purysko AS.Semin Ultrasound CT MR. 2025 Feb;46(1):83-89. doi: 10.1053/j.sult.2024.11.006. Epub 2024 Nov 22.PMID: 39580036 Review.

High-quality prostate magnetic resonance imaging (MRI) is required for accurate prostate cancer detection, localization, and staging. Variability in image quality exists in practice, influenced by inconsistent adherence to technical standards, lack of patient prepar …

I saw the "female prostate".

Srisajjakul S, Prapaisilp P, Bangchokdee S.Clin Imaging. 2024 Sep;113:110227. doi: 10.1016/j.clinimag.2024.110227. Epub 2024 Jun 20.PMID: 38909385 Review.

This article delves into the diagnostic implications of the female prostate sign, a distinctive radiological sign observed in magnetic resonance imaging of female patients with substantial urethral diverticula. ...Our findings support the enhanced recognition and understan …

Prostate as a target of endocrine disrupting chemicals: Relevance, pathways, assays.

Marcoccia D, Mollari M, Galli FS, Cuva C, Tassinari V, Mantovani A.Reprod Toxicol. 2025 Apr;133:108867. doi: 10.1016/j.reprotox.2025.108867. Epub 2025 Feb 27.PMID: 40020791 Review.

Prostate is essential for male fertility; indeed, the prostatic fluid is the main component of seminal fluid, which is essential for the activation and capacitation of sperm cells. Furthermore, the prostate is tightly regulated by androgen signaling and is an …

PRECISE Version 2: Updated Recommendations for Reporting Prostate Magnetic Resonance Imaging in Patients on Active Surveillance for Prostate Cancer.

Englman C, Maffei D, Allen C, Kirkham A, Albertsen P, Kasivisvanathan V, Baroni RH, Briganti A, De Visschere P, Dickinson L, Gómez Rivas J, Haider MA, Kesch C, Loeb S, Macura KJ, Margolis D, Mitra AM, Padhani AR, Panebianco V, Pinto PA, Ploussard G, Puech P, Purysko AS, Radtke JP, Rannikko A, Rastinehad A, Renard-Penna R, Sanguedolce F, Schimmöller L, Schoots IG, Shariat SF, Schieda N, Tempany CM, Turkbey B, Valerio M, Villers A, Walz J, Barrett T, Giganti F, Moore CM.Eur Urol. 2024 Sep;86(3):240-255. doi: 10.1016/j.eururo.2024.03.014. Epub 2024 Mar 30.PMID: 38556436 Free article.

BACKGROUND AND OBJECTIVE: The Prostate Cancer Radiological Estimation of Change in Sequential Evaluation (PRECISE) recommendations standardise the reporting of prostate magnetic resonance imaging (MRI) in patients on active surveillance (AS) for prostate canc …

Fully Automated Deep Learning Model to Detect Clinically Significant Prostate Cancer at MRI.

Cai JC, Nakai H, Kuanar S, Froemming AT, Bolan CW, Kawashima A, Takahashi H, Mynderse LA, Dora CD, Humphreys MR, Korfiatis P, Rouzrokh P, Bratt AK, Conte GM, Erickson BJ, Takahashi N.Radiology. 2024 Aug;312(2):e232635. doi: 10.1148/radiol.232635.PMID: 39105640

Background Multiparametric MRI can help identify clinically significant prostate cancer (csPCa) (Gleason score 7) but is limited by reader experience and interobserver variability. ...

Urologic Imaging of the Prostate: Cancer and Mimics.

Hajati A, Herold A, Catalano OA, Harisinghani MG.Urol Clin North Am. 2025 Feb;52(1):125-138. doi: 10.1016/j.ucl.2024.07.012. Epub 2024 Aug 16.PMID: 39537298 Review.

This article provides a comprehensive overview of prostate cancer imaging, including detection of clinically significant cancer and initial staging. ...The article also highlights the importance of differentiating benign prostatic conditions from prostate can …

MRI-based virtual pathology of the prostate.

Chatterjee A, Dwivedi DK.MAGMA. 2024 Aug;37(4):709-720. doi: 10.1007/s10334-024-01163-w. Epub 2024 Jun 10.PMID: 38856839 Review.

Prostate cancer poses significant diagnostic challenges, with conventional methods like prostate-specific antigen (PSA) screening and transrectal ultrasound (TRUS)-guided biopsies often leading to overdiagnosis or miss clinically significant cancers. ...These method …

Cite

[Prostate Surgery for Benign Prostatic Syndrome >200 ml: Endoscopic, Robotic, or Open Approach].

Hartung FO, Gruene B, Becker B, Rassweiler-Seyfried MC, Miernik A, Lusuardi L, Herrmann TR, Lehrich K, Netsch C, Herrmann J.Aktuelle Urol. 2024 Jun;55(3):213-218. doi: 10.1055/a-2307-3887. Epub 2024 May 28.PMID: 38806034 Review. German.

Surgical approaches for benign prostatic hyperplasia have evolved and diversified over the past decades. While numerous studies document the efficacy of surgical procedures for moderate prostate sizes, there remains insufficient data for large prostate volume …

Cite

Influence of microbiome in intraprostatic inflammation and prostate cancer.

Prakash P, Verma S, Gupta S.Prostate. 2024 Sep;84(13):1179-1188. doi: 10.1002/pros.24756. Epub 2024 Jun 20.PMID: 38899408 Review.

Microbial-produced metabolites have also been associated with signaling pathways that promote prostate cancer development. A comprehensive discussion on the mechanisms of microbiome infection and the prostate microenvironment is essential to understand prostate …

Cite

The Transatlantic Recommendations for Prostate Gland Evaluation with Magnetic Resonance Imaging After Focal Therapy (TARGET): A Systematic Review and International Consensus Recommendations.

Light A, Mayor N, Cullen E, Kirkham A, Padhani AR, Arya M, Bomers JGR, Dudderidge T, Ehdaie B, Freeman A, Guillaumier S, Hindley R, Lakhani A, Pendse D, Punwani S, Rastinehad AR, Rouvière O, Sanchez-Salas R, Schoots IG, Sokhi HK, Tam H, Tempany CM, Valerio M, Verma S, Villeirs G, van der Meulen J, Ahmed HU, Shah TT.Eur Urol. 2024 May;85(5):466-482. doi: 10.1016/j.eururo.2024.02.001. Epub 2024 Mar 21.PMID: 38519280 Free article.

Of 31 studies reporting MRI assessment criteria, the Prostate Imaging-Reporting and Data System (PI-RADS) score was the scheme used most often (20 studies; 65%), followed by a 5-point Likert score (six studies; 19%). ...CONCLUSIONS AND CLINICAL IMPLICATIONS: The TARGET con …

Cite

Strategies for improving image quality in prostate MRI.

Coelho FMA, Baroni RH.Abdom Radiol (NY). 2024 Dec;49(12):4556-4573. doi: 10.1007/s00261-024-04396-4. Epub 2024 Jun 28.PMID: 38940911 Review.

Prostate magnetic resonance imaging (MRI) stands as the cornerstone in diagnosing prostate cancer (PCa), offering superior detection capabilities while minimizing unnecessary biopsies. ...A comprehensive approach addressing technical, procedural, and interpretative …

Cite

From pituitary cells to prostate gland in health and disease: direct and indirect endocrine connections.

Sarmento-Cabral A, Fuentes-Fayos AC, Ordoñez FM, León-González AJ, Martínez-Fuentes AJ, Gahete MD, Luque RM.Rev Endocr Metab Disord. 2025 Apr;26(2):187-203. doi: 10.1007/s11154-025-09948-7. Epub 2025 Feb 6.PMID: 39910005 Review.

Particularly important for the endocrine control of prostatic pathophysiology and anatomy are hormones produced and/or secreted by different cell types of the pituitary gland [growth-hormone, luteinizing-hormone, follicle-stimulating hormone, and prolactin, oxytocin, argin …

Cite

Deep Learning Prostate MRI Segmentation Accuracy and Robustness: A Systematic Review.

Fassia MK, Balasubramanian A, Woo S, Vargas HA, Hricak H, Konukoglu E, Becker AS.Radiol Artif Intell. 2024 Jul;6(4):e230138. doi: 10.1148/ryai.230138.PMID: 38568094 Free PMC article.

Purpose To investigate the accuracy and robustness of prostate segmentation using deep learning across various training data sizes, MRI vendors, prostate zones, and testing methods relative to fellowship-trained diagnostic radiologists. ...Keywords: MRI, Genital/Rep …

Cite

Posttreatment Lower Urinary Tract and Prostate Imaging.

Nisar MU, Purysko AS, Ward RD.Urol Clin North Am. 2025 Feb;52(1):153-167. doi: 10.1016/j.ucl.2024.07.014. Epub 2024 Aug 16.PMID: 39537301 Review.

The treatment of benign and malignant diseases of the lower urinary tract and prostate gland can alter the anatomy and physiology of these regions. The radiologist should be familiar with the commonly performed procedures for conditions affecting the lower urinary tract as …

AMA APA MLA NLM

Page 3

Cite

[Development of endoscopic enucleation of the prostate].

Gross AJ, Rosenbaum C, Becker B, Netsch C.Aktuelle Urol. 2024 Jun;55(3):207-212. doi: 10.1055/a-2286-1243. Epub 2024 Apr 10.PMID: 38599594 Review. German.

This article deals with lasers from their initial description to the most advanced applications in the treatment of benign prostate enlargement....

Cite

Prostate Artery Embolization in the Setting of Prostate Cancer: Review and Opinion.

Parikh N, Yamoah K, Johnstone P, Torres-Roca J, Pow-Sang J, Fernandez D, Rishi A, Grass GD.Cancer Control. 2025 Jan-Dec;32:10732748251317691. doi: 10.1177/10732748251317691.PMID: 39876663 Free PMC article. Review.

Prostate Artery Embolization (PAE) is a novel minimally invasive angiographic technique that has been used effectively to treat men with lower urinary tract symptoms (LUTS) from benign prostatic hyperplasia (BPH). However, applications of PAE for men with prostat …

Cite

Diffusion-weighted MR spectroscopy of the prostate.

Stamatelatou A, Rizzo R, Simsek K, van Asten JJA, Heerschap A, Scheenen T, Kreis R.Magn Reson Med. 2024 Oct;92(4):1323-1337. doi: 10.1002/mrm.30141. Epub 2024 May 22.PMID: 38775024 Free article.

PURPOSE: Prostate tissue has a complex microstructure, mainly composed of epithelial and stromal cells, and of extracellular (acinar-luminal) spaces. ...METHODS: Nine healthy volunteers underwent a prostate MR examination (mean age, 56 years; range, 31-66). Metaboli …

Cite

Apparent differences in prostate zones: susceptibility to prostate cancer, benign prostatic hyperplasia and prostatitis.

Yu XD, Yan SS, Liu RJ, Zhang YS.Int Urol Nephrol. 2024 Aug;56(8):2451-2458. doi: 10.1007/s11255-024-04012-w. Epub 2024 Mar 25.PMID: 38528290 Review.

Men are inevitably plagued by prostate disease throughout their lives. However, the understanding of the pathogenesis of prostate diseases is still limited. In the 1960s, McNeal proposed the theory of prostate zones: the prostate was divided into three …

Cite

Acute and Chronic Prostatitis.

Lam JC, Stokes W.Am Fam Physician. 2024 Jul;110(1):45-51.PMID: 39028781 Review.

Prostatitis is a common clinical syndrome classified into four categories: acute bacterial, chronic bacterial, chronic prostatitis/chronic pelvic pain syndrome, and asymptomatic. ...Chronic prostatitis/chronic pelvic pain syndrome is the most common form of …

Cite

Metabolic imaging across scales reveals distinct prostate cancer phenotypes.

Sushentsev N, Hamm G, Flint L, Birtles D, Zakirov A, Richings J, Ling S, Tan JY, McLean MA, Ayyappan V, Horvat Menih I, Brodie C, Miller JL, Mills IG, Gnanapragasam VJ, Warren AY, Barry ST, Goodwin RJA, Barrett T, Gallagher FA.Nat Commun. 2024 Jul 16;15(1):5980. doi: 10.1038/s41467-024-50362-5.PMID: 39013948 Free PMC article.

Here we show that elevated hyperpolarised [1-(13)C]lactate signal in prostate cancer compared to the benign prostate is primarily driven by increased tumour epithelial cell density and vascularity, rather than differences in epithelial lactate concentration between …

Cite

Predicting prostate cancer grade reclassification on active surveillance using a deep learning-based grading algorithm.

Ding CC, Su ZT, Erak E, Oliveira LP, Salles DC, Jing Y, Samanta P, Bonthu S, Joshi U, Kondragunta C, Singhal N, De Marzo AM, Trock BJ, Pavlovich CP, de la Calle CM, Lotan TL.J Natl Cancer Inst. 2024 Oct 1;116(10):1683-1686. doi: 10.1093/jnci/djae139.PMID: 38889303

Deep learning (DL)-based algorithms to determine prostate cancer (PCa) Grade Group (GG) on biopsy slides have not been validated by comparison to clinical outcomes. ...In a contemporary validation cohort that underwent prostate magnetic resonance imaging before init …

Cite

Prostate-specific antigen, androgen, progesterone and oestrogen receptors in Benign prostatic hyperplasia: human tissues and animal model study.

Wang H, Liu C, Dong Z, Chen X, Zhang P.Aging Male. 2024 Dec;27(1):2391380. doi: 10.1080/13685538.2024.2391380. Epub 2024 Aug 14.PMID: 39140708 Free article.

BACKGROUND: Direct evidence for the relationship between a large prostate (80 ml) and androgen receptor/PSA signal remains lacking in benign prostatic hyperplasia (BPH). Our aim is to identify whether the cause of a large prostate is related to progesterone r …

Cite

Perspectives on technology: Prostate Imaging-Reporting and Data System (PI-RADS) interobserver variability.

Taya M, Behr SC, Westphalen AC.BJU Int. 2024 Oct;134(4):510-518. doi: 10.1111/bju.16452. Epub 2024 Jun 25.PMID: 38923789 Review.

OBJECTIVES: To explore the topic of Prostate Imaging-Reporting and Data System (PI-RADS) interobserver variability, including a discussion of major sources, mitigation approaches, and future directions. ...RESULTS: PI-RADS was developed in 2012 to set technical standards f …

Cite

Intrinsic and extrinsic factors causing hyperplasia of the prostate.

Kyoda Y, Shibamori K, Shindo T, Maehana T, Hashimoto K, Kobayashi K, Tanaka T, Fukuta F, Masumori N.Int J Urol. 2024 Jul;31(7):705-717. doi: 10.1111/iju.15446. Epub 2024 Mar 10.PMID: 38462732 Free PMC article. Review.

Prostatic hyperplasia is very common in elderly men and is a typical disease that reduces quality of life. ...Various factors have been considered to cause histological enlargement of the prostate, but the underlying cause is still unknown. The factors that cause …

AMA APA MLA NLM

Page 4

Cite

Prostate tissue ablation and drug delivery by an image-guided injectable ionic liquid in ex vivo and in vivo models.

Demirlenk YM, Albadawi H, Zhang Z, Atar D, Cevik E, Keum H, Kim J, Rehman S, Gunduz S, Graf E, Mayer JL, Dos Santos PR, Oklu R.Sci Transl Med. 2024 Jul 3;16(754):eadn7982. doi: 10.1126/scitranslmed.adn7982. Epub 2024 Jul 3.PMID: 38959326

Benign prostatic hyperplasia and prostate cancer are often associated with lower urinary tract symptoms, which can severely affect patient quality of life. ...Ultrasound-guided injection, dispersion of PADA in the tissue, and tissue ablation were tested ex vivo in h …

Cite

Image intensifier-guided transperineal prostate biopsy for patients without a rectum: novel technique.

McNicholas DP, Parr NJ.BJU Int. 2024 Apr;133(4):487-490. doi: 10.1111/bju.16279. Epub 2024 Jan 18.PMID: 38234225 Review.

INTRODUCTION: It is challenging to perform prostate biopsy in men with suspicion of prostate malignancy without a rectum to facilitate prostate biopsy. ...Using the above technique, biopsies were taken with low-risk prostate cancer diagnosed. Subsequen …

Cite

Picture Perfect: The Status of Image Quality in Prostate MRI.

Woernle A, Englman C, Dickinson L, Kirkham A, Punwani S, Haider A, Freeman A, Kasivisivanathan V, Emberton M, Hines J, Moore CM, Allen C, Giganti F.J Magn Reson Imaging. 2024 Jun;59(6):1930-1952. doi: 10.1002/jmri.29025. Epub 2023 Oct 7.PMID: 37804007 Review.

Magnetic resonance imaging is the gold standard imaging modality for the diagnosis of prostate cancer (PCa). Image quality is a fundamental prerequisite for the ability to detect clinically significant disease. ...As means of quality appraisal, the published literature on …

Cite

[The pathological processing of prostate biopsy and resection specimens].

Melegh Z, Németh K, Székely E, Borka K, Bori R, Semjén D, Pósfai B, Sükösd F, Salamon F, Bidiga L, Kuthi L.Magy Onkol. 2024 Jul 16;68(2):143-153. Epub 2024 May 19.PMID: 39013088 Free article. Review. Hungarian.

Prostate cancer stands as the most prevalent malignant tumor among men; with its incidence increasing with advancing age. ...Hence, it is imperative for pathologists to keep abreast of contemporary processing and specimen collection protocols, as well as the potential nece …

Cite

P2X7R Modulates NEK7-NLRP3 Interaction to Exacerbate Experimental Autoimmune Prostatitis via GSDMD-mediated Prostate Epithelial Cell Pyroptosis.

Chen L, Liu Y, Yue S, Wang H, Chen J, Ma W, Xu W, Xu M, Chen Z, Chen X, Zhang L, Liang C.Int J Biol Sci. 2024 Jun 11;20(9):3393-3411. doi: 10.7150/ijbs.94704. eCollection 2024.PMID: 38993566 Free PMC article.

Pyroptosis is a novel model of cell death, and its roles in chronic prostatitis are unknown. In this study, P2X7R, NEK7, and GSDMD-NT expression levels were detected in prostate tissues from benign prostate hyperplasia (BPH) patients and experiment autoimmune …

Cite

Update on PI-RADS Version 2.1 Diagnostic Performance Benchmarks for Prostate MRI: Systematic Review and Meta-Analysis.

Oerther B, Nedelcu A, Engel H, Schmucker C, Schwarzer G, Brugger T, Schoots IG, Eisenblaetter M, Sigle A, Gratzke C, Bamberg F, Benndorf M.Radiology. 2024 Aug;312(2):e233337. doi: 10.1148/radiol.233337.PMID: 39136561

Background Prostate MRI for the detection of clinically significant prostate cancer (csPCa) is standardized by the Prostate Imaging Reporting and Data System (PI-RADS), currently in version 2.1. ...Purpose To provide estimates of diagnostic accuracy and cance …

Cite

Role of MRI in Active Surveillance of Prostate Cancer.

Chappidi MR, Lin DW, Westphalen AC.Semin Ultrasound CT MR. 2025 Feb;46(1):31-44. doi: 10.1053/j.sult.2024.11.002. Epub 2024 Nov 26.PMID: 39608681 Review.

Magnetic resonance imaging (MRI) plays an important role in the management of patients with prostate cancer on active surveillance. In this review, we will explore the incorporation of MRI into active surveillance protocols, detailing its impact on clinical decision-making …

Cite

Imaging Assessment of Prostate Cancer Extra-prostatic Extension: From Histology to Controversies.

Torres CVS, Gouvea GL, Secaf AF, Vieira DFM, Morgado ASM, Palma MM, Ramos GA, Elias J Jr, Muglia VF.Semin Ultrasound CT MR. 2025 Feb;46(1):45-55. doi: 10.1053/j.sult.2024.11.003. Epub 2024 Nov 23.PMID: 39586413 Review.

Prostate cancer (PCa) is the most common non-skin malignancy among men and the fourth leading cause of cancer-related deaths globally. Accurate staging of PCa, particularly the assessment of extra-prostatic extension (EPE), is critical for prognosis and treatment pl …

Cite

Additional findings in prostate MRI.

Porões F, Karampa P, Sartoretti T, Najberg H, Froehlich JM, Reischauer C, Thoeny HC.Cancer Imaging. 2025 Mar 11;25(1):29. doi: 10.1186/s40644-025-00846-4.PMID: 40069885 Free PMC article.

METHODS: In a single-center study, we retrospectively included 1282 patients undergoing prostate MRI between 01.10.2018 and 30.04.2022. Additional findings were defined as any pathology not located in the prostate or the seminal vesicles. ...The choice between exten …

Cite

Causal relationship between prostatic diseases and prostate cancer: a mendelian randomization study.

Huang J, Sun J, Wang K, Zheng L, Fan Y, Qian B.BMC Cancer. 2024 Jun 27;24(1):774. doi: 10.1186/s12885-024-12551-9.PMID: 38937672 Free PMC article.

BACKGROUND: Although it is thought that prostatitis or benign prostatic hyperplasia (BPH) is related to prostate cancer (PCa), the underlying causal effects of these diseases are unclear. ...The association of genetic variants from cohorts of prostatitis …

AMA APA MLA NLM

Page 5

Cite

The role of urology and radiology in prostate biopsy: current trends and future perspectives.

Mac Curtain BM, Temperley HC, Kelly JAO, Ryan J, Qian W, O'Sullivan N, Breen KJ, Mc Carthy CJ, Brennan I, Davis NF.World J Urol. 2024 Apr 22;42(1):249. doi: 10.1007/s00345-024-04967-6.PMID: 38649544 Review.

PURPOSE: Prostate biopsy is central to the accurate histological diagnosis of prostate cancer. In current practice, the biopsy procedure can be performed using a transrectal or transperineal route with different technologies available for targeting of lesions within …

Cite

Association between cathepsins and benign prostate diseases: a bidirectional two-sample Mendelian randomization study.

Cao H, Liu B, Gong K, Wu H, Wang Y, Zhang H, Shi C, Wang P, Du H, Zhou H, Wang S.Front Endocrinol (Lausanne). 2024 Jun 5;15:1348310. doi: 10.3389/fendo.2024.1348310. eCollection 2024.PMID: 38904040 Free PMC article.

OBJECTIVES: The relationship between cathepsins and prostate cancer (PCa) has been reported. However, there is a lack of research on cathepsins and benign prostate diseases (BPDs). ...Our findings revealed that cathepsin O was beneficial in preventing BPH, whereas c …

Cite

Stromal androgen signaling governs essential niches in supporting prostate development and tumorigenesis.

Rhee JW, Adzavon YM, Sun Z.Oncogene. 2024 Nov;43(47):3419-3425. doi: 10.1038/s41388-024-03175-1. Epub 2024 Oct 5.PMID: 39369165 Free PMC article. Review.

Androgens and androgen receptor (AR) mediated signaling pathways are essential for prostate development, morphogenesis, growth, and regeneration. Early tissue recombination experiments showed that AR-deficient urogenital sinus mesenchyme combined with intact urogenital sin …

Cite

Prostate Magnetic Resonance Imaging Using the Prostate Imaging for Recurrence Reporting (PI-RR) Scoring System to Detect Recurrent Prostate Cancer: A Systematic Review and Meta-analysis.

Mourato FA, Schmitt LG, Mariussi M, Torri G, Altmayer S, Giganti F, Abreu-Gomez J, Perlis N, Berlin A, Ghai S, Haider MA, Dias AB.Eur Urol Oncol. 2024 Dec;7(6):1246-1254. doi: 10.1016/j.euo.2024.05.007. Epub 2024 May 31.PMID: 38824004 Review.

BACKGROUND AND OBJECTIVE: Prostate Imaging for Recurrence Reporting (PI-RR) was introduced in 2021 to standardize the interpretation and reporting of multiparametric magnetic resonance imaging (MRI) for prostate cancer following whole-gland treatment. ...Primary stu …

Cite

PLA inhibits TNF-alpha-induced PANoptosis of prostate cancer cells through metabolic reprogramming.

Hao Y, Xie F, He J, Gu C, Zhao Y, Luo W, Song X, Shen J, Yu L, Han Z, He J.Int J Biochem Cell Biol. 2024 Apr;169:106554. doi: 10.1016/j.biocel.2024.106554. Epub 2024 Feb 24.PMID: 38408537

Previous studies have shown that phenyllactic acid (alpha-Hydroxyhydrocinnamic acid, 2-Hydroxy-3-phenylpropionic acid, PLA), a type of organic acid metabolite, has excellent diagnostic efficacy when used to differentiate between prostate cancer, benign prostatic hyp …

Cite

Isolated Prostate Tuberculosis Mimicking Prostate Cancer.

Legesse TK, Issa SA, Yaynishet YA, Dessie TA, Gebremariam TY, Reta BK.Ethiop J Health Sci. 2024 Oct;34(Spec Iss 1):67-72. doi: 10.4314/ejhs.v34i1.10S.PMID: 39735520 Free PMC article.

He had previously undergone transurethral resection of the prostate (TURP), with histopathological findings suggestive of benign prostatic hyperplasia (BPH). ...Magnetic Resonance Imaging (MRI} raised high suspicion for locally advanced prostate cancer; howev …

Cite

4D pathology: translating dynamic epithelial tubulogenesis to prostate cancer pathology.

Harikumar H, van Royen ME, van Leenders GJ.Histopathology. 2025 Apr;86(5):681-693. doi: 10.1111/his.15354. Epub 2024 Oct 20.PMID: 39428716 Free PMC article. Review.

The Gleason score is the gold standard for grading of prostate cancer (PCa) and is assessed by assigning specific grades to different microscopical growth patterns. ...

Cite

High clonal diversity and spatial genetic admixture in early prostate cancer and surrounding normal tissue.

Zhang N, Harbers L, Simonetti M, Diekmann C, Verron Q, Berrino E, Bellomo SE, Longo GMC, Ratz M, Schultz N, Tarish F, Su P, Han B, Wang W, Onorato S, Grassini D, Ballarino R, Giordano S, Yang Q, Sapino A, Frisén J, Alkass K, Druid H, Roukos V, Helleday T, Marchiò C, Bienko M, Crosetto N.Nat Commun. 2024 Apr 24;15(1):3475. doi: 10.1038/s41467-024-47664-z.PMID: 38658552 Free PMC article.

In contrast, aneuploid cells do not form subclones and are detected throughout the prostate, including normal tissue regions. Highly localized pseudo-diploid subclones are confined within tumor-rich regions and carry deletions in multiple tumor-suppressor genes. Our study …

Cite

Identification and analysis of microplastics in para-tumor and tumor of human prostate.

Deng C, Zhu J, Fang Z, Yang Y, Zhao Q, Zhang Z, Jin Z, Jiang H.EBioMedicine. 2024 Oct;108:105360. doi: 10.1016/j.ebiom.2024.105360. Epub 2024 Sep 27.PMID: 39341155 Free PMC article.

Additionally, the potential correlation between microplastics abundance and prostate cancer are investigated. METHODS: Paired para-tumor and tumor samples of the prostate were collected from 22 patients who underwent robot-assisted radical prostatectomy. ...Addition …

Cite

A systematic review of robot-assisted simple prostatectomy outcomes by prostate volume.

Morozov A, Bogatova S, Bezrukov E, Singla N, Teoh JY, Spivak L, Rivas JG, Lusuardi L, Gauhar V, Somani B, Lifshitz D, Baniel J, Herrmann TRW, Enikeev D.World J Urol. 2024 Oct 8;42(1):565. doi: 10.1007/s00345-024-05264-y.PMID: 39377921 Free PMC article. Review.

In the lack of data on implementation of RASP in small prostate volumes, this procedure can be seen as an upper size "limitless" treatment alternative. Currently, comparative data regarding prostate volume is lacking, and future trials with subgroups analysis relate …

AMA APA MLA NLM

Page 6

Cite

Diagnostic Accuracy of PSMA PET-Guided Prostate Biopsy in Prostate Cancer-A Systematic Review and Meta-analysis.

Aggarwal P, Gunasekaran V, Singh H, Kumar R, Satapathy S, Mittal BR.Clin Nucl Med. 2025 Jan 1;50(1):e26-e33. doi: 10.1097/RLU.0000000000005501. Epub 2024 Oct 14.PMID: 39466639 Review.

PURPOSE: Early diagnosis and treatment of prostate cancer (PC) are crucial for effective management and improved patient outcomes. Newer imaging modalities like prostate-specific membrane antigen PET have shown superior diagnostic performance in detecting PC and cli …

Cite

Comprehensive Prostate Fluid-Based Spectral Libraries for Enhanced Protein Detection in Urine.

Ha A, Khoo A, Ignatchenko V, Khan S, Waas M, Vesprini D, Liu SK, Nyalwidhe JO, Semmes OJ, Boutros PC, Kislinger T.J Proteome Res. 2024 May 3;23(5):1768-1778. doi: 10.1021/acs.jproteome.4c00009. Epub 2024 Apr 5.PMID: 38580319 Free PMC article.

To evaluate various DIA-MS workflows, we collected urine from a clinically heterogeneous cohort of prostate cancer patients and acquired data in DDA and DIA scan modes. We then searched the DIA data against urine spectral libraries generated using common library generation …

Cite

Identification of impactful imaging biomarker: Clinical applications for breast and prostate carcinoma.

Bäuerle T, Dietzel M, Pinker K, Bonekamp D, Zhang KS, Schlemmer HP, Bannas P, Cyran CC, Eisenblätter M, Hilger I, Jung C, Schick F, Wegner F, Kiessling F.Rofo. 2024 Apr;196(4):354-362. doi: 10.1055/a-2175-4446. Epub 2023 Nov 9.PMID: 37944934 Free article. Review. English, German.

In this way, the clinical application of imaging biomarkers is increasing, as illustrated by the diagnosis of breast and prostate cancers. KEY POINTS: . Imaging biomarkers are quantitative parameters to detect physiological and pathophysiological processes.. . ...Quantitat …

Cite

Navigating the evolving diagnostic and therapeutic landscape of low- and intermediate-risk prostate cancer.

Zattoni F, Matrone F, Bortolus R, Giannarini G.Asian J Androl. 2024 Nov 1;26(6):549-556. doi: 10.4103/aja20249. Epub 2024 May 3.PMID: 38738954 Free PMC article. Review.

In this nonsystematic review of the literature, we explored the changing landscape of detection and treatment of low- and intermediate-risk prostate cancer (PCa). Through emphasizing improved cancer assessment with histology classification and genomics, we investigated key …

Cite

Beyond Prostate Imaging Reporting and Data System: Combining Magnetic Resonance Imaging Prostate Imaging Reporting and Data System and Prostate-Specific Membrane Antigen-Positron Emission Tomography/Computed Tomography PRIMARY Score in a Composite (P) Score for More Accurate Diagnosis of Clinically Significant Prostate Cancer.

Emmett L, Papa N, Hope TA, Fendler W, Calais J, Burger I, Eiber M, Barbato F, Moon D, Counter W, John N, Xue A, Franklin A, Thompson J, Rasiah K, Frydenberg M, Yaxley J, Buteau J, Agrawal S, Ho B, Nguyen A, Liu V, Lee J, Woo H, Hsiao E, Sutherland T, Perry E, Stricker P, Hofman MS, Kasivisvanathan V, Roberts M, Murphy D.J Urol. 2024 Aug;212(2):299-309. doi: 10.1097/JU.0000000000004010. Epub 2024 May 17.PMID: 38758680

PURPOSE: The Prostate Imaging Reporting and Data System (PI-RADS) score is standard of care for clinically significant prostate cancer (csPCa) diagnosis. The PRIMARY score (prostate-specific membrane antigen [PSMA]-positron emission tomography [PET]/CT) also …

Cite

Inflammation impacts androgen receptor signaling in basal prostate stem cells through interleukin 1 receptor antagonist.

Cooper PO, Yang J, Wang HH, Broman MM, Jayasundara SM, Sahoo SS, Yan B, Awdalkreem GD, Cresswell GM, Wang L, Goossens E, Lanman NA, Doerge RW, Zheng F, Cheng L, Alqahtani S, Crist SA, Braun RE, Kazemian M, Jerde TJ, Ratliff TL.Commun Biol. 2024 Oct 25;7(1):1390. doi: 10.1038/s42003-024-07071-y.PMID: 39455902 Free PMC article.

Chronic prostate inflammation in patients with benign prostate hyperplasia (BPH) correlates with the severity of symptoms. How inflammation contributes to prostate enlargement and/or BPH symptoms and the underlying mechanisms remain unclear. In this study, we …

Cite

Prostate Cancer Detection Rate of Transperineal Prostate Biopsy: Cognitive vs Software Fusion, A Multicenter Analysis.

Hung M, Ross AE, Li EV, Pavlovich CP, Fletcher SA, Gereta S, Zhang TR, McClure TD, Allaf ME, Schaeffer EM, Hu JC.Urology. 2024 Apr;186:91-97. doi: 10.1016/j.urology.2023.11.039. Epub 2024 Feb 20.PMID: 38387509

OBJECTIVE: To compare clinically significant prostate cancer detection with TP-TBx utilizing software vs cognitive fusion. It is established that MRI prior to prostate biopsy improves detection of clinically significant cancer (csPCa, Grade Group 2). ...MATERIALS AN …

Cite

CXCR4 regulates macrophage M1 polarization by altering glycolysis to promote prostate fibrosis.

Zhang Y, Zhang C, Feng R, Meng T, Peng W, Song J, Ma W, Xu W, Chen X, Chen J, Liang C.Cell Commun Signal. 2024 Sep 26;22(1):456. doi: 10.1186/s12964-024-01828-y.PMID: 39327570 Free PMC article.

METHODS: Use inducible experimental chronic prostatitis as a model of prostatic fibrosis. Reduce CXCR4 expression in immortalized bone marrow-derived macrophages using lentivirus. ...Additionally, in vivo functional experiments using AAV carrying CXCR4 showed that b …

Cite

Prostate size, source configuration, and dosimetry dynamics of stranded (125)I seed implants.

Sloboda RS, Liu D, Chng N, Wachowicz K, Usmani N.Brachytherapy. 2024 Sep-Oct;23(5):497-513. doi: 10.1016/j.brachy.2024.03.008. Epub 2024 Jun 8.PMID: 38853064

PURPOSE: To quantify changes in prostate size and seed movement over time after transperineal implantation of stranded (125)I seeds, and to determine their impact on prostate dosimetry. ...Prostate volume and dimensions, seed movements, and prostate do …

Cite

Radiomics for the identification of extraprostatic extension with prostate MRI: a systematic review and meta-analysis.

Ponsiglione A, Gambardella M, Stanzione A, Green R, Cantoni V, Nappi C, Crocetto F, Cuocolo R, Cuocolo A, Imbriaco M.Eur Radiol. 2024 Jun;34(6):3981-3991. doi: 10.1007/s00330-023-10427-3. Epub 2023 Nov 13.PMID: 37955670 Free PMC article.

OBJECTIVES: Extraprostatic extension (EPE) of prostate cancer (PCa) is predicted using clinical nomograms. Incorporating MRI could represent a leap forward, although poor sensitivity and standardization represent unsolved issues. ...CLINICAL RELEVANCE STATEMENT: Radiomics …

AMA APA MLA NLM

Page 7

Cite

Emerging therapeutic frontiers in prostate health: Novel molecular targets and classical pathways in comparison with BPH and prostate cancer.

Hassan MS, Irfan HM, Alamgeer, Sarwar M, Jabbar Z, Nawaz S.Crit Rev Oncol Hematol. 2025 Feb;206:104590. doi: 10.1016/j.critrevonc.2024.104590. Epub 2024 Dec 6.PMID: 39647642 Review.

Current therapeutic strategies for benign prostatic hyperplasia (BPH) and prostate cancer focus mainly on androgen receptors (AR) and 5-alpha reductase inhibition to suppress androgen-driven prostate growth. ...Data was compiled from Google Scholar, PubMed, a …

Cite

Standard Repeat Biopsies During Active Surveillance for Prostate Cancer: Are They Necessary in the Magnetic Resonance Imaging Era?

van den Bergh RCN, Schoots IG, Cornford PA; European Association of Urology Prostate Cancer Guidelines Panel.Eur Urol. 2025 Jan;87(1):5-7. doi: 10.1016/j.eururo.2024.09.014. Epub 2024 Sep 25.PMID: 39327115

Active surveillance (AS) remains an important part of the efforts to decrease overtreatment of prostate cancer. The increasing use of magnetic resonance imaging (MRI) can reduce the need for repeat biopsy during AS. If MRI findings remain unchanged and clinical characteris …

Cite

A novel simplified transperineal prostate biopsy guided by perineal ultrasound.

Xiao Y, Zeng Y, Han L, Lin G, Ke H, Xu S, Lyu G, Li S.Br J Radiol. 2024 Jun 18;97(1159):1351-1356. doi: 10.1093/bjr/tqae097.PMID: 38781498

BACKGROUND: Prostate biopsies are mainly performed through transrectal or perineal approaches, while ultrasound probes are located in the rectum for guidance. ...Simultaneously, 188 patients who underwent transrectal prostate biopsy (TRPB) were included as control. …

Cite

Meta-Analysis of Transperineal and Transrectal Ultrasound-Guided Prostate Biopsy in the Detection of Prostate Cancer.

Fang Y, Xia L, Lu H, He H.Arch Esp Urol. 2024 Nov;77(9):1089-1099. doi: 10.56434/j.arch.esp.urol.20247709.152.PMID: 39632532 Free article.

BACKGROUND: Transperineal (TP) biopsy is increasingly used as an alternative to standard transrectal (TR) biopsy for prostate cancer detection to reduce infection risks. However, evidence on comparative diagnostic accuracy remains inconclusive. ...TP biopsy may be consider …

Cite

3.0-T MR-guided transgluteal in-bore-targeted prostate biopsy under local anesthesia in patients without rectal access: a single-institute experience and review of literature.

Bera K, Ramaiya N, Paspulati RM, Nakamoto D, Tirumani SH.Abdom Radiol (NY). 2024 Apr;49(4):1223-1230. doi: 10.1007/s00261-024-04183-1. Epub 2024 Feb 21.PMID: 38383816 Free PMC article. Review.

Of the 13 biopsies, 4 yielded clinically significant prostate cancer (csPca), with a Gleason score 7, 1 yielded insignificant prostate cancer (Gleason score = 6), 7 yielded benign prostatic tissue, and one was technically unsuccessful. 3/13 biopsies were repe …

Cite

PROSTATE CANCER DIAGNOSTICS MODELING USING THE INFRARED IMAGING METHOD.

Partsvania B, Sulaberidze T, Khuskivadze A, Abazadze S.Exp Oncol. 2024 Dec 19;46(3):268-272. doi: 10.15407/exp-oncology.2024.03.268.PMID: 39704453

MATERIALS AND METHODS: Experiments were carried out on prostates obtained after radical prostatectomy. The study was approved by the ethical commission of the Georgia-Israel Joint Clinic "Gidmedi". We developed a device that uses IR light to illuminate a prostate fr …

Cite

Machine Learning to Predict Prostate Artery Embolization Outcomes.

Vigneswaran G, Doshi N, Maclean D, Bryant T, Harris M, Hacking N, Farrahi K, Niranjan M, Modi S.Cardiovasc Intervent Radiol. 2024 Sep;47(9):1248-1254. doi: 10.1007/s00270-024-03776-z. Epub 2024 Jun 19.PMID: 38896298 Free PMC article.

PURPOSE: This study leverages pre-procedural data and machine learning (ML) techniques to predict outcomes at one year following prostate artery embolization (PAE). MATERIALS AND METHODS: This retrospective analysis combines data from the UK-ROPE registry and patients that …

Cite

A clinical prostate biopsy dataset with undetected cancer.

Chelebian E, Avenel C, Järemo H, Andersson P, Wählby C, Bergh A.Sci Data. 2025 Mar 11;12(1):423. doi: 10.1038/s41597-025-04758-7.PMID: 40069192 Free PMC article.

Prostate cancer is a heterogeneous disease showing variability both among individuals and within a patient. ...Our clinical dataset comprises men with raised prostate-specific antigen but whose initial prostate needle biopsies only contained benign tissue. .. …

Cite

Cutibacterium acnes invades prostate epithelial cells to induce BRCAness as a possible pathogen of prostate cancer.

Ashida S, Kawada C, Tanaka H, Kurabayashi A, Yagyu KI, Sakamoto S, Maejima K, Miyano S, Daibata M, Nakagawa H, Inoue K.Prostate. 2024 Aug;84(11):1056-1066. doi: 10.1002/pros.24723. Epub 2024 May 9.PMID: 38721925

BACKGROUND: Abundant evidence suggests that chronic inflammation is linked to prostate cancer and that infection is a possible cause of prostate cancer. METHODS: To identify microbiota or pathogens associated with prostate cancer, we investigated the transcri …

Cite

The first reported values of microplastics in prostate.

Demirelli E, Tepe Y, Oğuz U, Aydın H, Kodat M, Tok DS, Sönmez MG, Öğreden E.BMC Urol. 2024 May 14;24(1):106. doi: 10.1186/s12894-024-01495-8.PMID: 38745203 Free PMC article.

Herein, it was aimed to investigate the presence of microplastics in prostate tissue. METHODS: Prostate tissues from 12 patients who underwent Trans Urethral Resection of the Prostate (TUR-P) were analyzed to investigate the presence of microplastics. Initial …

AMA APA MLA NLM

Page 8

Cite

Clinically Significant Prostate Cancer Detection Following Transrectal and Transperineal Biopsy: Results of the Prostate Biopsy Efficacy and Complications Randomized Clinical Trial.

Mian BM, Feustel PJ, Aziz A, Kaufman RP Jr, Bernstein A, Fisher HAG.J Urol. 2024 Jul;212(1):21-31. doi: 10.1097/JU.0000000000003979. Epub 2024 May 3.PMID: 38700844 Clinical Trial.

PURPOSE: The comparative effectiveness of transrectal and transperineal prostate biopsy in detecting clinically significant prostate cancer is not well understood. ...Of these, 384 underwent transrectal and 398 underwent transperineal prostate biopsy. Prebiop …

Cite

The 'Prostate Embolisation AS first-line therapY compAred to meDication in treatment naiVe men with prostAte eNlargement, a randomised ControllEd trial' (P-EASY ADVANCE): a randomised controlled trial of prostate embolisation vs medication for BPH.

Brown N, Kiosoglous A, Castree S, Firouzmand S, McBean R, Walker DG, Wallace S, Kua B, Gianduzzo T, Esler RC, Campbell P, Schoeman J, Yaxley J.BJU Int. 2024 Dec;134 Suppl 2(Suppl 2):38-46. doi: 10.1111/bju.16479. Epub 2024 Aug 13.PMID: 39139009 Free PMC article. Clinical Trial.

OBJECTIVE: To compare prostate artery embolisation (PAE) to the combination of tamsulosin and dutasteride therapy as a potential first-line therapy for obstructive benign prostatic hyperplasia (BPH) in treatment-naive patients in the 'Prostate Embolisation AS …

Cite

Characterization of prostate macrophage heterogeneity, foam cell markers, and CXCL17 upregulation in a mouse model of steroid hormone imbalance.

Silver SV, Tucker KJ, Vickman RE, Lanman NA, Semmes OJ, Alvarez NS, Popovics P.Sci Rep. 2024 Sep 9;14(1):21029. doi: 10.1038/s41598-024-71137-4.PMID: 39251671 Free PMC article.

Benign prostatic hyperplasia (BPH) is a prevalent age-related condition often characterized by debilitating urinary symptoms. ...Our study identified macrophage subsets that responded to steroid hormone imbalance as well as further confirmed a potential pathological role o …

Cite

Preoperative Prostate Magnetic Resonance Imaging-based Anatomical Predictors of Early Urinary Continence Following Single-port Transvesical Robot-assisted Radical Prostatectomy.

Ramos R, Shankar PR, Soputro NA, Bullen J, Pedraza AM, Chavali JS, Mikesell CD, Ward R, Purysko A, Kaouk J.Eur Urol Focus. 2024 Dec;10(6):1027-1033. doi: 10.1016/j.euf.2024.05.025. Epub 2024 Jun 12.PMID: 38866663 Free article.

At 1 wk, several parameters, including anteroposterior diameter of the prostate, coronal membranous urethra length, prostate volume, and transverse diameter of the prostate, showed promise in predicting continence. ...With the SP robot, accessing the prost …

Cite

Bidirectional influence between benign prostatic hyperplasia, prostate cancer, and prostatitis and mental disorders: two-sample and multivariate mendelian randomization analyses.

Chen X, Ren C, Wang Q, Liu X.Aging Male. 2024 Dec;27(1):2419853. doi: 10.1080/13685538.2024.2419853. Epub 2024 Oct 25.PMID: 39460452 Free article.

BACKGROUND: We aimed to use Mendelian randomization (MR) to determine the causality between fifteen major mental disorders (MDs) and benign prostatic hyperplasia (BPH), prostate cancer (PCa), and prostatitis. METHODS: The main MR analysis was performed using …

Cite

Prostate size 100 g and its association with long-term outcomes of Retzius-sparing robot-assisted radical prostatectomy.

Maltzman O, Tappero S, Caviglia A, Palagonia E, Buratto C, Chierigo F, Cellini V, Olivero A, Barbieri M, Secco S, Bocciardi AM, Galfano A, Dell'Oglio P.World J Urol. 2024 May 2;42(1):283. doi: 10.1007/s00345-024-04985-4.PMID: 38695988

BACKGROUND: It is unknown whether perioperative and functional outcomes of Retzius-sparing robot-assisted radical prostatectomy (RS-RARP) may be affected by large prostate sizes (PS). METHODS: All patients treated with RS-RARP were identified and compared according to PS. …

Cite

The Protective Effects of an Aged Black Garlic Water Extract on the Prostate.

Libero ML, Montero-Hidalgo AJ, Recinella L, Luque RM, Generali D, Acquaviva A, Orlando G, Ferrante C, Menghini L, Di Simone SC, Nilofar N, Chiavaroli A, Brunetti L, Leone S.Nutrients. 2024 Sep 7;16(17):3025. doi: 10.3390/nu16173025.PMID: 39275340 Free PMC article.

Chronic inflammation is a recognized risk factor for various cancers, including prostate cancer (PCa). We aim to explore the potential protective effects of aged black garlic extract (ABGE) against inflammation-induced prostate damage and its impact on prostate …

Cite

Mixed Supervision of Histopathology Improves Prostate Cancer Classification From MRI.

Rajagopal A, Westphalen AC, Velarde N, Simko JP, Nguyen H, Hope TA, Larson PEZ, Magudia K.IEEE Trans Med Imaging. 2024 Jul;43(7):2610-2622. doi: 10.1109/TMI.2024.3382909. Epub 2024 Jul 1.PMID: 38547000

Non-invasive prostate cancer classification from MRI has the potential to revolutionize patient care by providing early detection of clinically significant disease, but has thus far shown limited positive predictive value. ...We evaluated our model on a dataset of 973 (tes …

Cite

Use of Decipher Prostate Biopsy Test in Patients with Favorable-risk Disease Undergoing Conservative Management or Radical Prostatectomy in the Surveillance, Epidemiology, and End Results Registry.

Zhu A, Proudfoot JA, Davicioni E, Ross AE, Petkov VI, Bonds S, Schussler N, Zaorsky NG, Jia AY, Spratt DE, Schaeffer EM, Liu Y, Strasser MO, Hu JC.Eur Urol Oncol. 2024 Dec;7(6):1504-1512. doi: 10.1016/j.euo.2024.06.007. Epub 2024 Jul 6.PMID: 38972832

BACKGROUND AND OBJECTIVE: The extent of prostate cancer found on biopsy, as well as prostate cancer grade and genomic tests, can affect clinical decision-making. ...PATIENT SUMMARY: In this population analysis of men with favorable-risk prostate cancer, those …

Cite

MRI-Targeted Prostate Fusion Biopsy: What Are We Missing outside the Target? Implications for Treatment Planning.

Oderda M, Dematteis A, Calleris G, Diamand R, Gatti M, Marra G, Adans-Dester G, Al Salhi Y, Pastore A, Faletti R, Gontero P.Curr Oncol. 2024 Jul 22;31(7):4133-4140. doi: 10.3390/curroncol31070308.PMID: 39057180 Free PMC article.

Prostate cancer and csPCa were diagnosed by TBx in 100 (10%) and 82 (8%) SBx-negative cases and by SBx in 86 (9%) and 54 (6%) TBx-negative cases (p < 0.001). ...SBx after TBx should always be considered given the risk of missing other csPCa foci within the prostate …

AMA APA MLA NLM

Page 9

Cite

Radical Prostatectomy Without Prior Biopsy in Selected Patients Evaluated by (18)F-Labeled Prostate-Specific Membrane Antigen-Ligand Positron Emission Tomography/Computed Tomography and Multiparameter Magnetic Resonance Imaging: A Single-Center, Prospective, Single-Arm Trial.

Niu S, Ding X, Liu B, Ao L, Wang H, Chen W, Xu B, Olivero A, Liu J, Gao J, Gao Y, Fu W, Ma X, Li H, Wang B, Liu Y, Zhang X.J Urol. 2024 Aug;212(2):280-289. doi: 10.1097/JU.0000000000004025. Epub 2024 Jun 17.PMID: 38885328 Clinical Trial.

MATERIALS AND METHODS: Patients with a rising PSA level ranging from 4 to 30 ng/mL were scheduled for multiparametric (mp) MRI and (18)F-labeled prostate-specific membrane antigen (PSMA) positron emission tomography (PET). Forty-seven patients (cT2N0M0) with Prostate …

Cite

Transperineal Versus Transrectal Magnetic Resonance Imaging-targeted Biopsies for Prostate Cancer Diagnosis: Final Results of the Randomized PERFECT trial (CCAFU-PR1).

Ploussard G, Barret E, Fiard G, Lenfant L, Malavaud B, Giannarini G, Almeras C, Aziza R, Renard-Penna R, Descotes JL, Rozet F, Beauval JB, Salin A, Rouprêt M.Eur Urol Oncol. 2024 Oct;7(5):1080-1087. doi: 10.1016/j.euo.2024.01.019. Epub 2024 Feb 24.PMID: 38403523 Clinical Trial.

BACKGROUND: Recent guidelines favor transperineal (TP) prostate biopsies over the transrectal (TR) approach due to a reduced sepsis risk. Yet, evidence from controlled trial comparing both approaches within the MRI-targeted pathway for significant prostate cancer (P …

Cite

Primary squamous cell carcinoma of the prostate.

Mak G, Chew K, Wood D, Thompson J.BMJ Case Rep. 2024 Nov 14;17(11):e262520. doi: 10.1136/bcr-2024-262520.PMID: 39542500

Primary squamous cell carcinoma of the prostate is a rare entity, with limited documented cases in the medical literature. Herein, we present a case of primary prostatic squamous cell carcinoma in a male in his 60s, detailing the clinical presentation, diagnostic wo …

Cite

A prospective evaluation of the prostate microbiome in malignant and benign tissue using transperineal biopsy.

Chen VS, James C, Khemmani M, Desai S, Doshi C, Rac G, Ellis JL, Patel HD, Barkan GA, Gupta GN, Flanigan RC, Wolfe AJ.Prostate. 2024 Sep;84(13):1251-1261. doi: 10.1002/pros.24763. Epub 2024 Jun 30.PMID: 38946139

BACKGROUND: The link between the prostate microbiome and prostate cancer remains unclear. Few studies have analyzed the microbiota of prostate tissue, and these have been limited by potential contamination by transrectal biopsy. ...Patients were excluded if t …

Cite

Comparison of Multiparametric MRI-targeted and Systematic Biopsies for Detection of Cribriform and Intraductal Carcinoma Prostate Cancer.

Ghai S, Klotz L, Pond GR, Kebabdjian M, Downes MR, Belanger EC, Moussa M, van der Kwast TH.Radiology. 2024 Jul;312(1):e231948. doi: 10.1148/radiol.231948.PMID: 39012252 Clinical Trial.

Background Intraductal carcinoma (IDC) and invasive cribriform (Cr) subtypes of prostate cancer (PCa) are an indication of aggressiveness, but the evidence regarding whether MRI can be used to detect Cr/IDC-pattern PCa is contradictory. ...Targeted biopsy was performed in …

Cite

Prostate Imaging for Recurrence Reporting System Made Easy: A Case-Based Review of Prostate Cancer Local Recurrence on Magnetic Resonance Imaging.

Antunes PM, Sabaneeff N, Correia ETO, Bittencourt LK.Semin Ultrasound CT MR. 2025 Feb;46(1):56-70. doi: 10.1053/j.sult.2024.11.004. Epub 2024 Nov 22.PMID: 39580038 Review.

Prostate cancer (PCa) is one of the most prevalent cancers worldwide. Even following appropriate initial treatments, a subset of the patients develops tumor recurrence. ...Recently, an expert consensus proposed a scoring system for MRI-based assessment of local recurrence, …

Cite

Expect the unexpected: investigating discordant prostate MRI and biopsy results.

Stanzione A, Lee KL, Sanmugalingam N, Rajendran I, Sushentsev N, Caglič I, Barrett T.Eur Radiol. 2024 Jul;34(7):4810-4820. doi: 10.1007/s00330-024-10702-x. Epub 2024 Mar 20.PMID: 38503918 Free PMC article.

OBJECTIVES: To evaluate discrepant radio-pathological outcomes in biopsy-naive patients undergoing prostate MRI and to provide insights into the underlying causes. MATERIALS AND METHODS: A retrospective analysis was conducted on 2780 biopsy-naive patients undergoing pro …

Cite

Different diagnostic strategies combining prostate health index and magnetic resonance imaging for predicting prostate cancer: A multicentre study.

Zhu M, Fu Q, Zang Y, Shao Z, Zhou Y, Jiang Z, Wang W, Shi B, Chen S, Zhu Y.Urol Oncol. 2024 May;42(5):159.e17-159.e23. doi: 10.1016/j.urolonc.2024.02.009. Epub 2024 Mar 13.PMID: 38480077

OBJECTIVE: To explore how prostate health index (PHI) and multiparametric magnetic resonance imaging (mpMRI) should be used in concert to improve diagnostic capacity for clinically significant prostate cancers (CsCaP) in patients with prostate-specific antige …

Cite

Multispecies comparative prostate anatomy by imaging: Implications for experimental models of prostatic disease.

Berg FM, Correia ETO, Abenojar EC, Basilion JP, Rosol TJ, Baroni RH, Exner AA, Bittencourt LK.Prostate. 2024 May;84(7):682-693. doi: 10.1002/pros.24685. Epub 2024 Mar 13.PMID: 38477025

BACKGROUND: There is an increasing interest in using preclinical models for development and assessment of medical devices and imaging techniques for prostatic disease care. Still, a comprehensive assessment of the prostate's radiological anatomy in primary preclinic …

Cite

Analysis of environmental pollutant Bisphenol F elicited prostate injury targets and underlying mechanisms through network toxicology, molecular docking, and multi-level bioinformatics data integration.

Huang S.Toxicology. 2024 Aug;506:153847. doi: 10.1016/j.tox.2024.153847. Epub 2024 Jun 2.PMID: 38830480

The results indicate that BPF exposure can contribute to the initiation and progression of prostate cancer and prostatic hyperplastic by modulating apoptosis and proliferation, altering nerve function in blood vessel endothelial cells, and disrupting androgen metabo …

AMA APA MLA NLM

Page 10

Cite

Huang S.Toxicology. 2024 Aug;506:153847. doi: 10.1016/j.tox.2024.153847. Epub 2024 Jun 2.PMID: 38830480

Cite

A mixed Mamba U-net for prostate segmentation in MR images.

Du Q, Wang L, Chen H.Sci Rep. 2024 Aug 28;14(1):19976. doi: 10.1038/s41598-024-71045-7.PMID: 39198553 Free PMC article.

The diagnosis of early prostate cancer depends on the accurate segmentation of prostate regions in magnetic resonance imaging (MRI). However, this segmentation task is challenging due to the particularities of prostate MR images themselves and the limitations …

Cite

AI-derived Tumor Volume from Multiparametric MRI and Outcomes in Localized Prostate Cancer.

Yang DD, Lee LK, Tsui JMG, Leeman JE, McClure HM, Sudhyadhom A, Guthier CV, Taplin ME, Trinh QD, Mouw KW, Martin NE, Orio PF, Nguyen PL, D'Amico AV, Shin KY, Lee KN, King MT.Radiology. 2024 Oct;313(1):e240041. doi: 10.1148/radiol.240041.PMID: 39470422

Purpose To evaluate whether the total volume of intraprostatic tumor from AI-generated segmentations (V(AI)) provides independent prognostic information in patients with localized prostate cancer treated with radiation therapy (RT) or radical prostatectomy (RP). Materials …

Cite

Different Prostatic Tissue Microbiomes between High- and Low-Grade Prostate Cancer Pathogenesis.

Kim JH, Seo H, Kim S, Rahim MA, Jo S, Barman I, Tajdozian H, Sarafraz F, Song HY, Song YS.Int J Mol Sci. 2024 Aug 16;25(16):8943. doi: 10.3390/ijms25168943.PMID: 39201629 Free PMC article.

To investigate the association between an imbalance of bacteria and prostate carcinoma, the microbiome and gene functionality from tissues of patients with high-grade prostate tumor (HGT) and low-grade prostate tumor (LGT) were compared utilizing next-generat …

Cite

Can 3D Multiparametric Ultrasound Imaging Predict Prostate Biopsy Outcome?

Chen P, Turco S, Wang Y, Jager A, Daures G, Wijkstra H, Zwart W, Huang P, Mischi M.Ultrasound Med Biol. 2024 Aug;50(8):1194-1202. doi: 10.1016/j.ultrasmedbio.2024.04.007. Epub 2024 May 11.PMID: 38734528 Free article.

OBJECTIVES: To assess the value of 3D multiparametric ultrasound imaging, combining hemodynamic and tissue stiffness quantifications by machine learning, for the prediction of prostate biopsy outcomes. METHODS: After signing informed consent, 54 biopsy-naive patients under …

Cite

Correlation of Prostate High-Resolution Microultrasound With Multiparametric Magnetic Resonance Imaging.

Pickersgill NA, Alkazemi MH, Ostergar A, Joseph K, Vetter JM, Barashi NS, Kim EH, Andriole GL, Sivaraman A.Urology. 2025 Mar;197:33-39. doi: 10.1016/j.urology.2024.11.048. Epub 2024 Nov 28.PMID: 39615700

The Prostate Risk Identification using MicroUS (PRI-MUS) protocol was utilized to risk stratify prostate lesions, with PRI-MUS 3-5 defined as positive. ...Meanstandard deviation age was 65.61.5years and prostate-specific antigen was 7.60.6ng/mL. Ninety-two pa …

Cite

Prostate cancer lesions in transition zone exhibit a higher propensity for pathological upgrading in radical prostatectomy.

Chen X, Wang H, Wang C, Qian C, Lin Y, Huang Y, Wei X, Hou J.World J Urol. 2024 Oct 30;42(1):608. doi: 10.1007/s00345-024-05294-6.PMID: 39476187 Free PMC article.

BACKGROUND: The varying malignancy and lethality of different grades of prostate cancer (PCa) highlight the importance of accurate diagnosis. This study aims to evaluate the upgrading of transition zone (TZ) prostate cancer biopsies and identify factors to improve T …

Cite

Prostate MRI Transitional Zone Volume Predicts BPH Enucleation Volume Better than Alternative Modalities.

Forbes CM, Peterson CJ, Miller NL.J Endourol. 2024 Dec;38(12):1395-1399. doi: 10.1089/end.2024.0280. Epub 2024 Sep 20.PMID: 39276105

Introduction: Guidelines for benign prostate hyperplasia (BPH) interventions are volume based. The degree to which different imaging modalities actually correlate to treated volume is not known for BPH. ...Focusing on MRI-TZ volume rather than total prostate volume …

Cite

Prostate volume on computed tomography correlates well with magnetic resonance imaging measurements and is reproducible across rater training levels.

Iorga M, Useva A, Regan B, Pinkhasov A, Byler T, Wiener S.Int Urol Nephrol. 2024 Oct;56(10):3241-3247. doi: 10.1007/s11255-024-04036-2. Epub 2024 May 22.PMID: 38776056

BACKGROUND: Data are lacking for the accuracy of computed tomography (CT) in measuring prostate size, which can streamline care and prevent invasive procedures. We evaluate agreement and intra/inter-observer variability in prostate sizing between CT and magnetic res …

100

Cite

Prostatic Artery Embolisation Versus Transurethral Resection of the Prostate for Benign Prostatic Obstruction: 5-year Outcomes of a Randomised, Open-label, Noninferiority Trial.

Müllhaupt G, Hechelhammer L, Graf N, Mordasini L, Schmid HP, Engeler DS, Abt D.Eur Urol Focus. 2024 Sep;10(5):788-795. doi: 10.1016/j.euf.2024.03.001. Epub 2024 Mar 25.PMID: 38531756 Clinical Trial.

BACKGROUND AND OBJECTIVE: Prostatic artery embolisation (PAE) and transurethral resection of the prostate (TURP) are two of the surgical options for treatment of lower urinary tract symptoms/benign prostatic obstruction (LUTS/BPO). ...PATIENT SUMMARY: In this …